Teprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats
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概要
- 論文の詳細を見る
We examined whether the increasing action of teprenone (TP) on mucus synthesis and content in rat gastric mucosa is related to nitric oxide (NO) formation via NO synthase (NOS) in the tissue. TP (200 mg/kg)-induced increases in levels of gastric mucosal hexosamine and adherent mucus were inhibited with decreased gastric mucosal NOS activity and nitrite/nitrate concentration by co-administration of NG-monomethyl L-arginine (100 mg/kg), a NOS inhibitor, but not its D-isomer. These results suggest that TP exerts an increasing action on gastric mucus synthesis and content possibly under the condition of maintained NO production via NOS in gastric mucosal tissues, although the precise mechanisms for the action of TP is still unclear.
- 社団法人 日本薬理学会の論文
- 1998-12-01
著者
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Ohta Yoshiji
Department Of Biochemistry School Of Medicine Fujita Health University
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ISHIGURO Isao
Department of Biochemistry, School of Medicine, Fujita Health University
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Ishiguro I
Fujita Health Univ. Aichi Jpn
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Ishiguro Isao
Department Of Biochemistry School Of Medicine Fujita Health University
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Nishida Keiji
Department Of Biochemistry School Of Medicine Fujita Health University
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Ohta Y
Fujita Health Univ. Aichi Jpn
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Nishida Kenji
Department Of Materials Science Toyohashi University Of Technology
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Nishida Kenji
Department of Biochemistry, School of Medicine, Fujita Health University
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