Cimetidine Inhibits the Induction of Long-Term Potentiation in the Dentate Gyrus of Rats In Vivo

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated the effect of cimetidine, a clinically used H<SUB>2</SUB>-receptor antagonist, on the induction of long-term potentiation (LTP)in the dentate gyrus of anesthetized rats. Intracerebroventricular injection of cimetidine (50-100 nmol)inhibited the induction of LTP in a dose-dependent manner. The inhibitory effect of cimetidine was not mimicked by other H<SUB>2</SUB>-receptor antagonists (ranitidine, famotidine)or the H<SUB>1</SUB>-receptor antagonist diphenhydramine or the H<SUB>3</SUB>-receptor antagonist thioperamide. These results suggest that cimetidine inhibits hippocampal synaptic plasticity by a novel brain mechanism unrelated to H<SUB>1</SUB>, H<SUB>2</SUB> or H<SUB>3</SUB> receptors.

• 社団法人 日本薬理学会の論文
• 1997-07-01

著者

• SAITO HIROSHI

  Department of Neurology, Tohoku University School of Medicine

• ABE Kazuho

  Faculty of Pharmacy, Musashino University

• Abe K

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo:japan

• Abe Kazuho

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Chang Ming

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Saito Hiroshi

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Saito H

  Hirosaki Univ. School Of Medicine Hirosaki Jpn

• Saito Hiroshi

  Department of Applied Chemistry, Graduate School of Engineering, Tohoku University

関連論文

• 5歳以下発症日本人1型糖尿病発症に関する免疫学的特徴に関する検討
• The Secular Trend in the Incidence of Subarachnoid Hemorrhage in Miyagi, Japan : 1979-1990
• Relationship between the Required Coefficient of Friction and Gait Initiation in Young Adults on a Low Friction Floor
• Frequencies of factors of metabolic syndrome at diagnosis in children with T2DM
• Modulation of Voltage-Gated Ca^ Current by 4-Hydroxynonenal in Dentate Granule Cells(Highlighted paper setected by Editor-in-cfiief)(Pharmacology)
• Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells
• Morphine augments excitatory synaptic transmission in the dentate gyrus through GABAergic disinhibition
• Defect in an Intrahepatic Degradation of Apolipoprotein B in Suncus: An Animal Model of Hypobetalipoproteinemia^1
• Role of Acyl Coenzyme A Cholesterol Acytransferase in Intrahepatic Processing of apo B-Lipoprotein in Suncus
• Defect in Assembly Process of Very-Low-Density Lipoprotein in Suncus Liver: An Animal Model of Fatty Liver
• Minimally Invasive Direct Coronary Artery Bypass Grafting for Third-Time Coronary Artery Revascularization
• SECRETORY MECHANISM AND PATHOPHYSIOLOGICAL ROLE OF HUMAN ATRIAL NATRIURETIC PEPTIDE IN MEN : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• SPECIALITY OF ATRIAL FIBRILLATION IN WPW SYNDROME : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• Tuberous sclerosis, associated with renal cell carcinoma and angiomyolipoma, in a patient who developed endstage renal failure after nephrectomy
• Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient
• A female patient with malarial nephropathy
• CLINICAL STUDY ON THE SURGICAL TREATMENT OF SEPTAL ACCESSORY PATHWAY IN THE WPW SYNDROME : Arrhythmias (II) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Effects of fadrozole and leuprorelin acetate on aromatase activity and cell proliferation in a human breast cancer cell line (SK-BR-3)
• Inhibitory Effects of Catecholamines and Maternal Stress on Aromatase Activity in the Fetal Rat Brain
• Video-Assisted Blebectomy Using a Flexible Scope and a Bleb Implement
• The Relationship of Thyroid Cancer with Radiation Exposure from Nuclear Weapon Testing in the Marshall Islands
• The intensity of scattered light in turbid seawater is a major factor in the turbiditaxis of Japanese anchovy larvae
• Hepatocellular Carcinoma with a Sarcomatous Appearance : Report of a Case
• Direct Calculation of Source Parasitic Resistance in AlGaAs/GaAs HEMTs
• Pleural Involvement of Dialysis-Related Amyloidosis
• The PPARγ Ligand, 15d-PGJ_2, Attenuates the Severity of Cerulein-Induced Acute Pancreatitis
• Pulmonary pleomorphic carcinoma producing hCG
• Poorly Differentiated Adenocarcinoma with Signet-Ring Cell Carcinoma in a Hyperplastic Polyp of the Stomach : Report of a Case
• Fabry disease in patients receiving maintenance dialysis
• Pharmacological Activities of Glycyrrhetinic Acid Derivatives : Analgesic and Anti-Type IV Allergic Effects(Medeicinal Chemistry,Chemical)
• -P121-ENDOTHELIN INHIBITS RENIN RELEASE FROM ISOLATED RAT GLOMERULI : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells
• A Japanese Family with Ferroportin Disease Caused by a Novel Mutation of SLC40A1 Gene: Hyperferritinemia Associated with a Relatively Low Transferrin Saturation of Iron
• Body iron stores and Iron restoration rate in Japanese patients with chronic Hepatitis C as measured during therapeutic Iron removal revealed neither Increased body iron stores nor effects of C282y and H63d mutations on iron indices
• New Analytical Method for Pancreas and Liver Regeneration : Normalization of Streptozotocin-Induced Hyperglycemia by Retrograde Injection of Insulin Producing Cells
• FACTORS AFFECTING ON SODIUM METABOLISM IN SHR (S). A SERIAL OBSERVATION FROM 4 TO 20 WEEKS OF AGE : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• -0281-ELECTROPHYSIOLOGIC AND HEMODYNAMIC STUDY FOR ATRIAL FIBRILLATION IN WOLFF-PARKINSON-WHITE SYNDROME
• Secondary Hyperparathyroidism in Patients on Maintenance Hemodialysis : Study of Optimal Hemopurification and Parathyroidectomy
• Growth Interruption Effect on the Formation of CdSe/ZnSe Quantum Dots
• Generation and Evaluation of Post-Heated Zinc and Selenium Molecular Beams
• A Case of Malignant Pheochromocytoma with Holt-Oram Syndrome
• Improvement of Fatigue and Acceleration of Recovery from Stress-Induced Deficient Sexual Behavior in Mice Following Oral Administration of Soft-Shelled Turtle Powder
• Anti-tumor Effects of Orally Administered Soft-Shelled Turtle Powder in Mice
• Human T-Lymphotropic Virus Type-I Infection, Antibody Titers and Cause-specific Mortality among Atomic-bomb Survivors
• PTHrP and PTH/PTHrP Receptor Expressions in Human Endometrium
• The Role of Parathyroid Hormone-Related Protein in Intra-Tracheal Fluid
• The Effect of Cytokines on Parathyroid Hormone-Related Protein (PTH-rP) Production in Human Amnion Cells
• Molecular Beam Epitaxially Grown ZnSe(001) Surface Studied by the In Situ Observation of RHEED Intensity
• Effect of Residual Strain on the Splitting of Excitonic Luminescence Lines in Epitaxially Grown ZnSe/GaAs
• Antagonistic Effect of N - (3 - Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons
• The Effects of Ethanol and Crocin on the Induction of Long-Term Potentiation in the CA1 Region of Rat Hippocampal Slices
• Structural Requirement for Neurotrophic Activity of Spermine in Cultured Rat Hippocampal Neurons
• Cushing's Syndrome due to Bilateral Adrenocortical Adenomas with Unique Histological Features
• Na^+ and K^+ Dependence of L-Glutamate-Induced Suppression of Astrocyte Stellation in Culture
• Activin Selectively Abolishes Hippocampal Long-Term Potentiation Induced by Weak Tetanic Stimulation In Vivo
• Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus
• Furosemide : Sensitive Calcium Rise Induced by GABA_A : Receptor Stimulation in Cultures of Embryonic Rat Striatal Neurons
• Involvement of a Peripheral Mechanism in the Emesis Induced by Cardiac Glycosides in Suncus murinus
• Body Mass Index Negatively Influences Glycated Albumin, but not Glycated Hemoglobin, in Diabetic Patients
• AC Flashover Characteristics on Trapezoidal Contamination Models of Actual Insulators
• IS-54 Production of Macrophage Migration Inhibitory Factor(MIF)from Granulosa Cells at Ovulatory Phase
• Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients
• Marine Molluscs Collected from the Shallow Waters of Hainan Island, South China Sea, by China-Japan Joint Research in 1997
• K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma
• Malignant transformation of endometriosis : application of laser microdissection for analysis of genetic alterations according to pathological changes
• Intravascular Large B Cell Lymphoma Diagnosed by Senile Angioma Biopsy
• Intramolecular Carbostannylation of Allyl- and Vinylstannanes via a Radical Chain Process
• Hydroxy Group-Directed Homolytic Hydrostannylation of Alkenols with Dibutylchlorostannane
• Recent advances in non-invasive prenatal DNA diagnosis through analysis of maternal blood
• Flow Velocity Measurement in Rotating Cavities by using Particle Image Velocimetry
• Heat Transfer and Pressure Drop Characteristics of a Heat Exchanger with Vortex Generators
• CP2289,a New 5-HT_3 Receptor Ligand : Agonistic Activities on Gastroenteric Motility
• 3β-Hydroxysteroid Dehydrogenase Activity in Human Osteoblast-Like Cells
• A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
• Low Temperature Growth of ZnSe/GaAs Using Post-Heated Molecular Beams
• β_1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo
• Optimum Culture Conditions for Production of Exfoliative Toxin by Staphylococcus hyicus
• High-frequency stimulation of the basolateral amygdala facilitates the induction of long-term potentiation in the dentate gyrus in vivo
• Roles of GABA^A, NMDA and muscarinic receptors in induction of long-term potentiation in the medial and lateral amygdala in vitro
• Effect of Hexacyanoferrate(III) on Mycobacterium smegmatis 7Fe Ferredoxin: Further Evidence for Formation of a 6Fe(2×[3Fe-4S]) Ferredoxin
• Diffuse neuroaxonal leukodystrophy with spheroids of adult onset: MRI and pathological studies
• Influence of the Hand Breaking at Sideways Falls : Sharing Effective Mass and Impact Force (Proceedings of the 54th Meeting of Japan Society of Physiological Anthropology)
• P1-6 Protetive Movements in Descent Phase of Foward and Backward Falls(Proceedings of the 50th Meeting of Japan Society of Physiological Anthropology)
• TOXICOLOGICAL STUDY ON RATS FED HALOPERIDOL: 80 WEEK CHRONIC TOXICITY TEST
• Cold agglutinin disease by autoanti-i blood type antibody associated with B cell chronic lymphocytic leukemia
• The Current Concepts of "Normal Values" and "Clinical Reference Values" in the Clinical Laboratory : Trials for Determining Clinical Reference Values of the Tokai University Hospital
• Evaluation of L-Glutamate Clearance Capacity of Cultured Rat Cortical Astrocytes
• Effects on Anticipatory Postural Adjustments by Repetition of the Tiptoe Movement
• Gait Control in Young Adults Trained on a Low Friction Floor
• Intracellular Calcium Oscillation in Cultured Rat Hippcampal Neurons: A Model for Glutamatergic Neurotransmission
• Successful Treatment of Blunt Trauma Involving Complete Laceration of the Pancreas and Duodenum in a 7 - Year - Old Child: Report of a Case
• CD56^+ acute myeloid leukemia with monosomy 7
• Coronal Cementogenesis in Cattle Molar Teeth
• Differential Effects of Microtubule Inhibitors on Axonal Branching and Elongation of Cultured Rat Hippocampal Neurons
• P-8 Anticipatory Muscle Activation of the Low Extremities during Lateral Step Initiation(Proceedings of the 51st Meeting of Japan Society of Physiological Anthropology)
• L-Glutamate Suppresses Astrocyte Stellation Induced by Actin Breakdown in Culture
• Selective Cytotoxicity of Piperine on Cultured Rat Hippocampal Neurons in Comparison with Cultured Astrocytes : The Possible Involvement of Lipid Peroxidation
• The Relationship of Thyroid Cancer with Radiation Exposure from Nuclear Weapon Testing in the Marshall Islands
• Neonatal behavioral assessment scale as a predictor of later developmental disabilities of low birth-weight and/or premature infants
• Traumatic Pseudoaneurysm of the Subclavian Artery Following Anterior Dislocation of the Shoulder : A Report of a Surgical Case

もっと見る 閉じる

スポンサーリンク