Modulation of Evoked Cerebral Blood Flow under Excessive Blood Supply and Hyperoxic Conditions
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概要
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We measured the field potential and local cerebral blood flow (LCBF) using laser-Doppler flowmetry in α-chloralose anesthetized rats during activation of the somatosensory cortex by electrical stimulation of the hind paw under independent administration of additional carbon dioxide and oxygen. The aim of this study was to test the hypothesis that the increase in LCBF during activation of the cortex (evoked LCBF) is not directed toward supplying oxygen for oxidative metabolism. Under the hypercapnic condition (PaCO2 = 74.9 ± 14.3 mmHg), the baseline LCBF was about 46.5% higher than that under the normocapnic condition (PaCO2 = 35.7 ± 2.1 mmHg) (p < 0.001), but after normalization for each baseline (divided by the prestimulus level), there was no significant difference in the peak value and the rise time of normalized evoked LCBF. On the other hand, the baseline level of LCBF under the hyperoxic condition (PaO2 = 479.4 ± 77.2 mmHg) was about 5.0% lower than that under the normoxic condition (PaO2 = 105.5 ± 7.8 mmHg) (p < 0.01), suggesting mild vasoconstriction under the condition of hyperoxia at rest. The peak value of normalized evoked LCBF under the hyperoxic condition was about 6.5% higher than that under the normoxic condition (p < 0.05). In addition, the rise time of evoked LCBF was earlier under the hyperoxic condition (0.37 ± 0.16 s) than that under the normoxic condition (0.52 ± 0.12 s) (p < 0.01). The field potential measured during stimulation under hypercapnic and hyperoxic conditions was not significantly different when compared with that under normal gas conditions. These results support our hypothesis and suggest that the excess oxygen is involved in the mechanism underlying the regulation of LCBF.
- 日本生理学会の論文
著者
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Fujita Hideaki
秋田県立脳血管研究センター
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Kanno Iwao
秋田県立脳血管研究センター
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Kanno I
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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KANNO Iwao
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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Kanno Iwao
Akita Research Institute Of Brain And Blood Vessels
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Fujita Hideaki
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute Of Brain And Bloo
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Kanno Iwao
Department Of Radiology And Nuclear Medicine Akita Research Institute For Brain And Vessels
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MATSUURA Tetsuya
Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute for Brain and B
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KASHIKURA Kenichi
Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute of Brain and Bl
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Kashikura Kenichi
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute Of Brain And Bloo
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Kanno Iwao
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Matsuura Tetsuya
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute Of Brain And Bloo
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Matsuura Tetsuya
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute For Brain And Blo
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