＜Poster＞Cerebrovascular dynamics in response to neural stimulation

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Cerebral blood flow is tightly regulated, and local metabolic demands are met by adjustments to theregional density of microvascular networks and by temporal and spatial changes in microvascular blood flow.Cerebral blood flow regulation may involve communication between and across the vascular cells and neural orglial cells in either rapid or slow conduits. In the present study, we report distinct diff erences between the dynamicreactions of cerebral arterial networks in cortical surface and in intracortical tissue regions in response to sensorystimulation. Using confocal and multi-photon excitation laser scanning fluorescence microscopy, we imaged thecortical surface and subsurface vascular networks in the somatosensory cortex of isoflurane-anesthetized rats.Changes in lumen diameter were imaged at a rate of 13 frames per second with a fi eld of view of 512 by 512 pixels.We consistently observed a stimulus-dependent increase in the lumen diameter of arterial networks in both corticalsurface and subsurface regions. The onset time of vasodilation was observed to be ~0.8 sec for the subsurfacearterioles（ <40 μm）, which was signifi cantly shorter than the ~1.1 sec vasodilation onset time of the surface arteries（20-120 μm）. The peak dilation accounted for 10% of the pre-stimulus baseline diameter. Further, the propagation ofsurface arterial vasodilation increased in a stimulus-dependent manner. The results indicate that global vasodilationof upstream parent arteries may be necessary to prevent “blood steal” by inactive regions nearby. Further studiesare needed to elucidate the physiological mechanisms underlying the propagation of vasodilation induced by neuralstimulation.

＜Poster＞Cerebrovascular dynamics in response to neural stimulation

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