Effect of cyclooxygenase-2 on the regulation of cerebral blood flow during neuronal activation in the rat
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概要
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The present study was designed to clarify the precision of the main approach for investigating the regulation of local cerebral blood flow (CBF) response to neuronal activation in the brain (neurovascular coupling). In this study, we examined the effects of NS-398, a highly selective cyclooxygenase-2 inhibitor, on the physiological variables, baseline CBF, and local CBF response during rat somatosensory neuronal activation by laser-Doppler flowmetry. Blood pressure and heart rate were significantly decreased 3 h after i.v. infusion of NS-398. Baseline CBF and local CBF during somatosensory activation gradually decreased with an increase in time of NS-398 infusion up to 3 h, although neuronal activity in the somatosensory area was almost constant during the infusion. The results suggest that cyclooxygenase-2 participates in the regulation of local CBF during neuronal activation in rats. The present study also revealed the potential side-effects of dimethylsulfoxide, a solvent of NS-398, on neurovascular coupling.http://www.elsevier.com/wps/find/journaldescription.cws_home/506082/description#description
- Elsevier B.V.の論文
- 2009-09-01
著者
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KANNO Iwao
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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Kanno Iwao
Molecular Imaging Center National Institute Of Radiological Sciences. Chiba
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Obata Takayuki
Department Of Medical Imaging National Institute Of Radiological Sciences
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Obata Takayuki
Molecular Imaging Center National Institute Of Radiological Sciences. Chiba
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Kanno Iwao
Department Of Radiology And Nuclear Medicine Akita Research Institute For Brain And Vessels
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Takuwa Hiroyuki
National Institute Of Radiological Science Chiba
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Takuwa Hiroyuki
Department Of Biology And Earth Sciences Faculty Of Science Ehime University
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Kanno Iwao
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Bakalova Rumiana
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Obata Takayuki
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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MATSUURA Tetsuya
Academic Group of Mathematical and Natural Science, Iwate University
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Matsuura Tetsuya
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Matsuura Tetsuya
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute Of Brain And Bloo
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