Frequency Dependence of Local Cerebral Blood Flow Induced by Somatosensory Hind Paw Stimulation in Rat under Normo- and Hypercapnia
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概要
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We measured the field potential and the changes in local cerebral blood flow (LCBF) response during somatosensory activation (evoked LCBF) in α-chloralose-anesthetized rats by laser-Doppler flowmetry under normocapnia (PaCO2=34.3±3.8 mmHg) and hypercapnia (PaCO2=70.1±9.8 mmHg). Somatosensory activation was induced by electrical stimulation (0.2, 1, and 5 Hz with 1.5 mA for 5 s) of the hind paw. The neuronal activity of the somatosensory area of the hind paw was linear to the stimulus frequency, and there was no significant difference in the neuronal activity between hypercapnia and normocapnia. The baseline level of LCBF under hypercapnia was about 72.2% higher than that under normocapnia (p<0.01). The absolute response magnitude under hypercapnia was greater than that under normocapnia (p<0.05). The evoked LCBF under both conditions showed a frequency-dependent increase in the 0.2 to 5 Hz range, and the difference in the absolute response magnitude at the same stimulus frequency between normocapnia and hypercapnia became large with increasing stimulus frequency (p<0.05). On the other hand, after normalization to each baseline level there was no significant difference in the response magnitude of the normalized evoked LCBF between normocapnia and hypercapnia, indicating that the normalized evoked LCBF reflects neuronal activity even when the baseline LCBF was changed by the PaCO2 level. The peak time and termination time of LCBF response curves with respect to the graded neuronal activity at 1 and 5 Hz stimulation increased significantly under hypercapnia, compared with those under normocapnia (p<0.05), although the rise time of 0.5 s was nearly constant. In conclusion, the results suggest a synergistic effect of the combined application of graded neuronal stimuli and hypercapnia on the LCBF response.
- 日本生理学会の論文
著者
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KANNO Iwao
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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Kanno Iwao
Department Of Radiology And Nuclear Medicine Akita Research Institute For Brain And Blood Vessels
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BAKALOVA Roumiana
Department of Radiology and Nuclear Medicine, Akita Research Institute for Brain and Blood Vessels
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MATSUURA Tetsuya
Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute for Brain and B
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Kanno Iwao
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Matsuura Tetsuya
Akita Laboratory Japan Science And Technology Corporation Akita Research Institute For Brain And Blo
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Bakalova Roumiana
Department Of Radiology And Nuclear Medicine Akita Research Institute For Brain And Blood Vessels
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KANNO Iwao
Department of Radiology and Nuclear Medicine, Akita Research Institute for Brain and Blood Vessels
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