Histamine H_3 Receptor-Mediated Inhibition of Excitatory Synaptic Transmission in the Rat Dentate Gyrus In Vivo
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概要
- 論文の詳細を見る
We investigated the effects of histamine H3-receptor ligands on hippocampal synaptic transmission by using anesthetized rats in vivo. The medial perforant path was stimulated, and the population excitatory postsynaptic potential (pEPSP) and population spike were recorded from the granule cell layer of the dentate gyrus. Intracerebroventricular injection of the H3-receptor agonist (R)-α-methylhistamine decreased both the pEPSP and population spike, while H3-receptor antagonists, clobenpropit and thioperamide, increased both the pEPSP and population spike. These results suggest that the histaminergic system plays a role in inhibition of hippocampal synaptic excitation via the H3 receptor.
- 社団法人 日本薬理学会の論文
- 1998-07-01
著者
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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ABE Kazuho
Faculty of Pharmacy, Musashino University
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Abe K
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo:japan
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Abe Kazuho
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Chang Ming
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Saito H
Hirosaki Univ. School Of Medicine Hirosaki Jpn
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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