The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Cerebellar Granular Cell Culture
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概要
- 論文の詳細を見る
In the present study, melatonin was tested in subsequent doses in glutamate induced neurotoxicity in cerebellar granular cell culture of rat pups. Glutamate at 10-7M was found to induce neuronal cell death. The dead cell score was 2.75±0.7 in the control, while it was found to be 35.12±1.8 in the glutamate-administered group (P<0.0001). Melatonin very potently blocked glutamate neurotoxicity at all doses tested, with 10-3M, the highest dose tested, being the most effective. Glutamate may exert a neuroprotective effect by blocking one or more steps of the oxidation cascade in neurons and this effect may be blocked by melatonin.
- 社団法人 日本薬理学会の論文
- 2000-12-01
著者
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GEPDIREMEN Akcahan
Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University
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Duzenli Selma
Departments Of Medical Genetics Ataturk Universty Medical Faculty
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Hacimuftuoglu Ahmet
Department Of Pharmacology Ataturk University Medical Faculty
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SULEYMAN Halis
Department of Pharmacology, Ataturk University, Medical Faculty
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BULUCU Dilek
Departments of Pharmacology, Ataturk University, Medical Faculty
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Bulucu Dilek
Departments Of Pharmacology Ataturk University Medical Faculty
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Sueleyman H
Atatuerk Univ. Erzurum Tur
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Suleyman Halis
Department Of Pharmacology Faculty Of Medicine Ataturk University
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Gepdiremen Akcahan
Department Of Pharmacology Faculty Of Medicine Ondokuz Mayis University
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