The Effect of Adrenalectomy on Leptin Levels and Some Metabolic Parameters in Rats with Diet-Induced Obesity

スポンサーリンク

概要

• 論文の詳細を見る

• Recently, there has been many investigations on the relationship between leptin and obesity, which is the main health problem in developed countries. In some reports, it has been claimed that the adrenalectomy has lead to weight loss and thus prevented obesity induced in rodents in various ways. It has also been accepted that diet-induced obesity in animals is very similar to obesity in humans beings. In this study, obesity has been developed with high-calorie diet given for 8 weeks in Sprague-Dawley rats. Then, it has been investigated how leptin and some metabolic parameters change in blood samples obtained from rats 15 d after adrenalectomy. Leptin levels was determined with Radio Immun Assay (RIA, Linco Research Co^[○!R]) method. Our study showed that,there were statistically significant increases in leptin (p<0.001), glucose (p<0.05), triglyceride (p<0.01) levels in diet-induced obese rats (n=19) when compared with the findings of control rats, lean ones (n=16), (Tables 3,4). Adrenalectomy led to decreased serum leptin (p<0.001) and triglyceride (p<0.01) levels both in the obese and lean rats (Table 5). As a conclusion, it could be claimed that the decrease in leptin levels may be attributed to reduced adipose tissue due to adrenalectomy. On the other hand, the decreases in glucose and triglyceride levels might be the consequence of reduced lipogenesis and impaired gluconeogenesis with the effect of adrenalectomy. It was concluded that adrenalectomy might prevent obesity by affecting leptin and intermediate metabolism.

• 公益社団法人日本薬学会の論文
• 2002-05-01

著者

• SULEYMAN Halis

  Department of Pharmacology, Ataturk University, Medical Faculty

• Suleyman H

  Department Of Pharmacology Faculty Of Medicine University Of Ataturk

• Suleyman Halis

  Department Of Pharmacology Faculty Of Medicine Ataturk University

• YILMAZ Adnan

  Department of Biochemistry Faculty of Medicine, University of Ataturk

• UMUDUM Zuhal

  Department of Biochemistry Faculty of Medicine, University of Ataturk

• SAHIN Yasar

  Department of Biochemistry Faculty of Medicine, University of Ataturk

• Sahin Yasar

  Department Of Biochemistry Faculty Of Medicine University Of Ataturk

• Umudum Zuhal

  Department Of Biochemistry Faculty Of Medicine University Of Ataturk

• Yilmaz Adnan

  Department Of Biochemistry Faculty Of Medicine University Of Ataturk

関連論文

• Nitric Oxide Donor Sodium Nitroprusside Induces Neurotoxicity in Cerebellar Granular Cell Culture in Rats by an Independent Mechanism from L-Type or Dantrolene-Sensitive Calcium Channels(Pharmacology)
• The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Cerebellar Granular Cell Culture
• Beneficial Effects of Hippophae rhamnoides L. on Nicotine Induced Oxidative Stress in Rat Blood Compared with Vitamin E
• Gastroprotective and Antioxidant Effects of Montelukast on Indomethacin-Induced Gastric Ulcer in Rats
• Anti-inflammatory Activity of Bis(3-aryl-3-oxo-propyl)methylamine Hydrochloride in Rat(Pharmacology)
• The Effect of Adrenalectomy on Leptin Levels and Some Metabolic Parameters in Rats with Diet-Induced Obesity
• Sedative Effect of Centranthus longiflorus ssp. longiflorus in Rats and the Influence of Adrenalectomy on its Effect
• Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models
• The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats
• The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells

スポンサーリンク