Gastroprotective and Antioxidant Effects of Montelukast on Indomethacin-Induced Gastric Ulcer in Rats

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概要

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• Montelukast, a selective reversible cysteinyl leukotriene D4-receptor (LTD4 receptor) antagonist, is used in the treatment of asthma. We have investigated alterations in the glutathione (GSH) and activity levels of antioxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione reductase (GR)] and myeloperoxidase (MPO), as markers of the ulceration process following oral administration of montelukast, lansoprazole, famotidine, and ranitidine, respectively, in rats with indomethacin-induced ulcers. In the present study, we found that 1) montelukast, lansoprazole, famotidine, and ranitidine all reduced the development of indomethacin-induced gastric damage, with this reduction occurring at a greater magnitude for montelukast, famotidine, and lansoprazole than for ranitidine; 2) montelukast and ranitidine both alleviated increases in the activity levels of CAT and GST enzymes resulting from gastric injury; 3) montelukast and ranitidine both ameliorated depressions in the GSH and activity levels of SOD and GR enzymes caused by indomethacin administration; and 4) all doses of montelukast, lansoprazole, and ranitidine decreased amplification of MPO activity resulting from induced gastric injuries. These results suggest that the gastroprotective effects of montelukast on indomethacin-induced ulcerations can be attributed to its ameliorating effect on oxidative damage and MPO activity.

• 社団法人 日本薬理学会の論文
• 2007-09-20

著者

• SULEYMAN Halis

  Department of Pharmacology, Ataturk University, Medical Faculty

• Suleyman Halis

  Department Of Pharmacology Faculty Of Medicine Ataturk University

• DENGIZ Gunnur

  Department of Pharmacology, Faculty of Medicine, Karaelmas University

• ODABASOGLU Fehmi

  Department of Biochemistry, Ataturk University

• HALICI Zekai

  Department of Pharmacology, Faculty of Medicine, Ataturk University

• CADIRCI Elif

  Department of Pharmacology, Faculty of Pharmacy, Ataturk University

• Halici Zekai

  Department Of Pharmacology Faculty Of Medicine Ataturk University

• Cadirci Elif

  Department Of Pharmacology Faculty Of Pharmacy Ataturk University

• Dengiz Gunnur

  Department Of Pharmacology Faculty Of Medicine Karaelmas University

• Odabasoglu Fehmi

  Department Of Biochemistry Faculty Of Pharmacy Ataturk University

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