The Effects of Newly Synthesized Pyrazole Derivatives on Formaldehyde-, Carrageenan-, and Dextran-Induced Acute Paw Edema in Rats

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The antiinflammatory effects of l0 newly synthesized pyrazole derivatives on formaldehyde-induced rat paw edema were investigated. The most effective of them(K-3)was investigated again in dextran- and carrageenan-induced paw edema. In formaldehyde-induced paw edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the edema by 48.9%(p<0.002), 68.7%(p<0.001), and 79.1%(p<0.001), respectively, 3 h after administration. In dextran- induced paw edema, the same dose of K-3 produced 27.1%(p<0.05), 46.8%(p<0.0l), and 63.8%(p<0.002)inhibition, respectively. In the carrageenan-induced paw edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg.
公益社団法人日本薬学会の論文
2001-10-01