Radioprotective Effects of Melatonin on Radiation-Induced Cataract

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概要

• 論文の詳細を見る

• One of the mechanisms proposed to explain lens opacification is the oxidation of crystallins, either by radiation or reactive oxygen species (ROS). It has been shown that melatonin has both an anti-peroxidative effect on several tissues and a scavenger effect on ROS. The purpose of this study was to determine the antioxidant role of melatonin (5mg/kg/day) against radiation-induced cataract in the lens after totalcranium irradiation of rats with a single dose of 5Gy. Sprague-Dawley rats were divided into four groups. Control group received neither melatonin nor irradiation. Irradiated rats (IR) and melatonin+irradiated rats (IR+Mel) groups were exposed to total cranium irradiation of 5Gy in a single dose by using a cobalt-60 teletherapy unit. IR+Mel and melatonin (Mel) groups were administered 5mg/kg melatonin daily by intraperitoneal injections during ten days. Chylack's cataract classification was used in this study. At the end of the 10^<th> day, the rats were killed and their eyes were enucleated to measure the antioxidant enzymes i.e. the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and lipid peroxidation level (malondialdehyde (MDA)). Irradiation significantly increased the MDA level, as an end product of lipid peroxidation, and also significantly decreased SOD and GSH-Px activity, emphasizing the generation of increased oxidative stress. Rats injected with melatonin only did not cause cataract formation. Melatonin supplementation with irradiation significantly increased the activity of SOD and GSH-Px enzymes and significantly decreased the MDA level. Total cranium irradiation of 5Gy in a single dose enhanced cataract formation, and melatonin supplementation protected the lenses from radiation-induced cataract formation. Our results suggest that supplementing cancer patients with adjuvant therapy of melatonin may reduce patients suffering from toxic therapeutic regimens such as chemotherapy and/or radiotherapy and may provide an alleviation of the symptoms due to radiation-induced organ injuries.

• 日本放射線影響学会の論文
• 2005-06-30

著者

• Sezen Orhan

  Department Of Radiation Oncology Ataturk University Faculty Of Medicine

• Ertekin Mustafa

  Department Of Radiation Oncology Ataturk University Faculty Of Medicine

• KARSLIOGLU Ihsan

  Department of Radiation Oncology, Faculty of Medicine, Ataturk University

• TAYSI Seyithan

  Biochemistry, Faculty of Medicine, Ataturk University

• KOCER Ibrahim

  Ophthalmology, Faculty of Medicine, Ataturk University

• GEPDIREMEN Akcahan

  Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University

• KOC Mehmet

  Department of Radiation Oncology, Faculty of Medicine, Ataturk University

• BAKAN Nuri

  Biochemistry, Faculty of Medicine, Ataturk University

• KOCER Ibrahim

  Department of Ophthalmology, Ataturk University, Faculty of Medicine

• TAYSI Seyithan

  Department of Biochemistry, Ataturk University, Faculty of Medicine

• Koc Mehmet

  Department Of Radiation Oncology Faculty Of Medicine Ataturk University

• Kocer Ibrahim

  Ophthalmology Faculty Of Medicine Ataturk University

• Bakan N

  Biochemistry Faculty Of Medicine Ataturk University

• Taysi S

  Biochemistry Faculty Of Medicine Ataturk University

• Karsl1oglu Ihsan

  Department Of Radiation Oncology Faculty Of Medicine Ataturk University

• Gepdiremen Akcahan

  Department Of Pharmacology Faculty Of Medicine Ondokuz Mayis University

• TAYSI Seyithan

  Biochemistry

• BAKAN Nuri

  Biochemistry

• KARSLIOGLU Ihsan

  Department of Radiation Oncology

• ERTEKIN Mustafa

  Department of Radiation Oncology

• SEZEN Orhan

  Department of Radiation Oncology

関連論文

• Vitamin E and L-carnitine, Separately or in Combination, in The Prevention of Radiation-induced Oral Mucositis and Myelosuppression : a Controlled Study in A Rat Model
• Radioprotective Effects of Melatonin on Radiation-Induced Cataract
• The Effect of Zinc Sulphate in The Prevention of Radiation-induced Dermatitis
• Effects of Oral Ginkgo biloba Supplementation on Cataract Formation and Oxidative Stress Occurring in Lenses of Rats Exposed to Total Cranium Radiotherapy
• Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration
• Levels of some Acute-Phase Proteins in the Serum of Patients with Cancer during Radiotherapy(Medicinal Chemistry)
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• Nitric Oxide Donor Sodium Nitroprusside Induces Neurotoxicity in Cerebellar Granular Cell Culture in Rats by an Independent Mechanism from L-Type or Dantrolene-Sensitive Calcium Channels(Pharmacology)
• The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Cerebellar Granular Cell Culture
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• An Investigation of the Antiinflammatory Effects of an Extract from Cladonia rangiformis HOFFM.
• Melatonin Protects Rat Liver against Irradiation-induced Oxidative Injury
• The Effect of Melatonin on Peripheral Blood Cells during Total Body Irradiation in Rats
• Bond strengths of two conventional glass-ionomer cements to irradiated and non-irradiated dentin
• Protective effect of L-carnitine against bilirubin-induced neuronal cell death
• L-carnitine protects against glutamate- and kainic acid-induced neurotoxicity in cerebellar granular cell culture of rats

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