Vitamin E and L-carnitine, Separately or in Combination, in The Prevention of Radiation-induced Oral Mucositis and Myelosuppression : a Controlled Study in A Rat Model
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概要
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The aim of this study was to determine the effects of vitamin E (VE) and L-carnitine (LC) supplementation, separately or in combination, on radiation-induced oral mucositis and myelosuppression. Group 1 received no treatment (control). Group 2 received 15 Gray of ^<60>Co gamma irradiation as a single dose to total cranium (IR). Group 3, 4, and 5 received irradiation plus 40mg/kg/day VE (IR+VE) or 200mg/kg/day LC (IR+LC) or in combination (IR+VE+LC) respectively. Clinically and histopathologically, assessments of mucosal reactions were performed by two independent experts in Radiation Oncology and Pathology, respectively. Hematologic analyses and antioxidant enzyme evaluations were also performed. Irradiation significantly increased oral mucositis, and decreased thrombocyte and White Blood Cell counts. A significant increase in malondialdehyde (MDA) levels and decrease in superoxide dismutase (SOD) and catalase (CAT) activities in plasma were found in the IR group. VE and LC administration, separately, plus irradiation significantly delayed the starting day, and reduced the severity of, oral mucositis. This administration also reduced a fall in the numbers of thrombocyte and WBC caused by irradiation, and decreased the MDA level, and increased the activity of SOD and CAT enzymes in the plasma. VE and LC, in combination, plus irradiation did not provide a superior radioprotection against radiation-induced toxicities.
- 日本放射線影響学会の論文
- 2006-03-31
著者
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Sezen Orhan
Department Of Radiation Oncology Ataturk University Faculty Of Medicine
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Ertekin Mustafa
Department Of Radiation Oncology Ataturk University Faculty Of Medicine
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UCUNCU Harun
Department of Otolaryngology, Ataturk University, Faculty of Medicine
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YORUK Ozgur
Department of Otolaryngology, Ataturk University, Faculty of Medicine
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OZKAN Asuman
Department of Biochemistry, Ataturk University, Faculty of Medicine
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ERDOGAN Fazli
Department of Pathology, Ataturk University, Faculty of Medicine
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KiZiLTUNC Ahmet
Department of Biochemistry, Ataturk University, Faculty of Medic
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GUNDOGDU Cemal
Department of Pathology, Ataturk University, Faculty of Medicine
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Yoruk Ozgur
Department Of Otolaryngology Ataturk University Faculty Of Medicine
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Ucuncu Harun
Department Of Otolaryngology Ataturk University Faculty Of Medicine
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Ozkan Asuman
Department Of Biochemistry Ataturk University Faculty Of Medicine
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Kiziltunc Ahmet
Department Of Biochemistry Ataturk University Faculty Of Medic
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Erdogan Fazli
Department Of Neurosurgery School Of Medicine Ataturk University
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Gundogdu Cemal
Department Of Pathology Ataturk University Faculty Of Medicine
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ERTEKIN Mustafa
Department of Radiation Oncology
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SEZEN Orhan
Department of Radiation Oncology
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