Structure-function Studies on the Ligand/Receptor πInteractions

スポンサーリンク

概要

• 論文の詳細を見る
• 2003-02-01

著者

• Nose Takeru

  Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of

• Nose Takeru

  Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University

関連論文

• Design and Preparation of Universal Anti-PERIOD Antibodies and their Immunoresponses
• Chymotrypsin Inhibition Induced by Side Chain-Side Chain Intramolecular CH/π Interaction in D-Thr-L-Phe Benzylamide
• Ligand-inducing Conformation Changes in the Estrogen Receptor C-Terminal Tail Moiety and Their Sensing by Polyclonal Antibodies
• Aggregation Feature of Fluorine-Substituted Benzene Rings and Intermodular C-H…F Interaction: Crystal Structure Analyses of Mono- and Trifluoro-L-phenylalanines
• Structural Characterization of the Housefly PDF, A Circadian Rhythm Pacemaker Hormone
• The Structure-activity Studies of Drosophila FMRFamide-related Peptides
• Localization Profiles of the Precursor Protein of Circadian Rhythm Pacemaker Hormone PDF in Gryllus Brain
• Structural Characteristics of Drosophila Estrogen-related Receptor Ligand Binding Domain to Capture the Peptide and Non-peptide Ligands
• LOCALIZATION PROFILES OF ORCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF FLIES, MUSCA DOMESTICA(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• Localization Profiles of Circadian Neuropeptide PDF in Brain of the Cricket Gryllus Bimaculatus
• LOCALIZATION PROFILES OF CIRCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF CRICKET, GRYLLUS BIMACULATUS(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• α-Helix Peptides for Bio-Panning in the Phage Display Method to Obtain the Antibodies Specific for Conformation Change in Nuclear Receptors
• Highly Sensitive Monoclonal Antibodies to Distinguish Conformational Changes Induced by Endocrine Disrupting Chemicals in the Estrogen Receptor
• Specific Affinity Labeling of Cys60 in the δ Opioid Receptor by Npys-containing Dynorphin A Analog
• Differential Receptor Binding Characteristics of the Phenylalanine Residues at Positions 3-4 of Endomorphin-2
• The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor
• Exploration of the Role of Phenylalanine in the Thrombin Receptor Tethered-Ligand Peptide by Substitution with a Series of Trifluorophenylalanines
• The Mode of Molecular Interation of Phe-3 of Deltorphin II and Endomorphin 2 in Opioid Receptor Binding
• Receptor Interaction Mode of the Phe-phenyl Group of Opioid Peptides
• Exploration of Universal Cysteines in the Bining Sites of Therr Opioid Receptor Subtypes by Disulfide-Bonding Affinty Labeling with Chemically Activated Thiol-Containing Dynorphin A Analogs
• Affinity Labeling of Opioid Receptor Subtypes by Activated Thiol-containig Dynorphin A Analogs
• Different Roles of Two Consecutive Leucine Residues in a Receptor-Tethered Ligand Peptide (SFLLRNP) in Thrombin Receptor Activation
• The Conformation Change-Sensing Antibodies for Retinoid-Related Orphan Receptor Family
• Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
• The Molecular Mechanism of ORL1 Nociceptin Receptor in Activation : Residual Essentials in the Sixth Transmembrane Domain
• Structural Analysis of Excitatory Neuropeptides TEP-1 and TEP-2 Isolated from the Prosobranch Gastopod Thais clavigera
• Optimization of the N-Terminal Group of Ac-RYYRIK-NH_2 as ORL1 Receptor Antagonist
• Structural Profiles for Coacervation of Elastin-derived Polypeptides
• Reversible Affinity Labeling of Opioid Receptors via Disulfide Bonding: Discriminative Labeling of μ and δ Subtypes by Chemically Activated Thiol-Containing Enkephalin Analogs
• Isobutyryl-RYYRIK-NH_2, A Highly Potent Nociceptin Antagonist
• Conformation Change-sensing Assay Using Monoclonal Antibody for N-terminal Octapeptide Repreat Region of Prion Protein
• Structural Characterisitics of the N-Terminal Octapeptide Repeat Region of Prion Protein
• Structural Requirements of the N-terminal Octapeptide Repeat of Prion Protein
• Structural Requirement of the Acyl Group of Ac-RYYRIK-NH_2, an Antagonist of Algesic Neuropeptide Nociceptin
• Structure-Activity Studies on the Nociceptin Peptidic Antagonist Ac-RYYRIK-NH_2
• Synthesis of Pure Antagonist of ORL1 Nociceptin Receptor
• Residual Roles of Hydrophobic Amino Acids in the Fifth Transmembrane Domain of ORL1 Receptor in Its Activation
• Enkephalin Dimers Cross-Linked by Diaminobenzene for Homodimeric Opioid Receptors Expressed in COS-7 Cells
• Continuous Activation of the δ-Opioid Receptor by Affinity Labeling
• Biochemical Evaluation of Hormonal Activity of Endocrine Disruptors by Sensing the Estrogen Receptor Conformation Changes
• The Effect of the Peptide Corresponding to the No.12 α-Helix on the Estrogen Receptor Activation
• Specific Affinity Labeling of Delta Opioid Receptors via Thiol-Disulfide Exchange Reaction
• Identification of Receptor Residues Functioning for Activation of ORL1 Nociceptin Receptor by Site-directed Mutageneses
• Elastin-derived Peptides : Structure, Functions and Mechanisms
• RECEPTOR-MEDIATED BINDING OF ELASTIN-DERIVED HEXAPEPTIDE TO MACROPHAGES INDUCED A GALACTOSUGAR-SENSITIVE CHEMOTAXIS
• Structural Requirement of Nociceptive Peptide Nociceptin : Structural Importance of C-Terminal Fragment for Receptor Recognition
• Structure-Activity Relationships of a Naturally Occurring Nociceptive Peptide, Nociceptin
• Characteristic Intra- and Intermolecular Interactions of Dipeptide-Chymotrypsin Complex as Specific Structural Essentials for Enzyme Inhibition
• Identification of Receptor Binding Site of Nociceptin-14-15, the Residues for High Receptor Potentiation
• Synergistic Potentiation of Nociceptin by Simultaneous Incorporation of Basic Amino Acids at the Consecutive Positions 14-15
• Activity Enhancement by Introduction of Two Different Halogen Atoms into Phe-2-phenyl Group of Thrombin Receptor Tethered-Ligand Analogs
• Edge-to Face CH/π Interaction between Ligand Phe-Phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation
• Highly Potent Peptide Ligands for Thrombin Receptor
• Chemical Syntheses of Phenylalanine Derivatives Containing Halogenated Benzene Ring as Structural Explorers for Elucidation of Molecular Mechanisms of Receptor Interacions
• Desieg and Synthesis of para-Fluorophenylalanine Amide Derivatives as Thrombin Receptor Antagonists
• Importance of Ligand Phe-phenyl Group for Activation of Thrombin Receptor
• The Role of Arginine in Thrombin Receptor Tethered-Ligand Peptide in Intramolecular Receptor Binding and Self-Activation
• Effects of Substitution of Hydrophobic Amino Acids by Tryptophan on Receptor Binding and Biological Activity of Neuropeptide Nociceptin
• The Effects of Arg→Trp and Lys→Trp Substitutions for Arg-Lys^ Residues in a Superagonist [Arg-Lys^]-Nociceptin on the ORL1 Receptor Binding and Activation
• Molecular Mechanism of α-Helix Peptide That Inhibits Intermolecular Interaction of Prion Protein N-Terminal Tetrarepeat Domain
• Histidines as Structurally Essential Residue for the Delta Opioid Receptor Activation
• Essential Amino Acid Residues in the ORL1 Receptor Transmembrane Domains for Receptor Activation
• Design and Synthesis of para-Fluorophenylalanine Amide Derivatives Containing N-Terminal Thiol as Thrombin Receptor Antagonist
• Conformation Change of α-Helix Peptide for Sensing of Deactivation of Nuclear Receptor : Immunoassay Using Polyclonal Antibody Specific for the C-Terminal α-Helix 12 of Estrogen-Related Receptor γ(ERRγ)
• The Attempt to Identify the Binding Sites of Nociceptin Antagonist Ac-RYYRIK-NH_2 in ORL1 Receptor
• Hetero-Oligomer Formation of Peptides Derived from Tetramerization Domain in Tumor Suppressor Protein p53
• Leucine-14 of Nociceptin Is a Structural Element in the CH/π Interaction with the Receptor Aromatic Group
• Structural Requirements in Activation of Opioid Receptor-Like ORL1 Receptor by Nociceptin
• Structure-Activity Relationships of Serine Protease Inhibitors with Structural Element Stacking to the Catalytic Residue His-57
• The Effect of Structural Difference between Dipeptide C-Terminal Benzyl Amides and Esters on Chymotrypsin Inhibition
• Peptide Library-Derived Inhibitors of Lipolytic Enzyme Phospholipase A_2
• Contractile Activity of Drosophila FMRFamide-Related Peptides in the Meretrix Lusoria Heart Muscle
• cDNA Cloning of Circadian Rhythm Pacemaker Neuropeptide PDF in Gryllus bimaculatus and Its Nuclear Localization
• Conformation Sensing Assay Using Polyclonal Antibody Specific for the C-terminal α-helix of Glucocorticoid Receptor and Progesterone Receptor
• Bioactive Conformation of a D-Trp-Containing Cardioexcitatory Tripeptide Isolated from the Sea Hare Aplysia
• Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH_2 on the Conformation and Contractile Activity
• The Trp residue of opioid receptor TM5 present at the cell membrane interface is a molecular anchor for full activation
• Exploration of the Binding Site of ORL1 Nociceptin Receptor Antagonist
• Structure-function Studies on the Ligand/Receptor πInteractions
• Functional Analysis of a Histidine Residue Essential for Receptor Activation of Delta Opioid Receptor
• Receptor Binding Characteristics of Tritium-Labeled Pure Antagonist Peptide for Hyperalgesic Nociceptin ORL1 Receptor
• Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs
• Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation
• Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD
• Effects of the Halogenation of Phe-Phenyl Group of Two Consecutive Residues in Endomorphin-2 on the Interaction with the μ-Opioid Receptors
• The Effect of Halogenation of Phe-Phenyl Group of Two Consecutive Phe Residues Present in Neuropeptide Substance P on Its Specific Receptor Interaction
• High-precision Binding Assay Procedure of Tachykinin Receptor NK-1 for Highly Potent Substance P Analogs
• Bisphenol-binding Pocket of Constitutively Active Nuclear Receptor CAR: Docking Modeling for Close-packing
• Edge-to-Face CH/.PI. Interaction between Ligand Ph-Phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation.
• Exploration of Universal Cysteines in the Binding Sites of Three Opioid Receptor Subtypes by Disulfide-Bonding Affinity Labeling with Chemically Activated Thiol-Containing Dynorphin A Analogs.

もっと見る 閉じる

スポンサーリンク