Quasi-<i>In vivo</i> Heart Electrocardiogram Measurement of ST Period Using Convolution of Cell Network Extracellular Field Potential Propagation in Lined-Up Cardiomyocyte Cell-Network Circuit

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概要

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• A model for the quasi-<i>in vivo</i> heart electrocardiogram (ECG) measurement of the ST period has been developed. As the part of ECG data at the ST period is the convolution of the extracellular field potentials (FPs) of cardiomyocytes in a ventricle, we have fabricated a lined-up cardiomyocyte cell-network on a lined-up microelectrode array and a circular microelectrode in an agarose microchamber, and measured the convoluted FPs. When the ventricular tachyarrhythmias of beating occurred in the cardiomyocyte network, the convoluted FP profile showed similar arrhythmia ECG-like profiles, indicating the convoluted FPs of the <i>in vitro</i> cell network include both the depolarization data and the propagation manner of beating in the heart.

• 2011-07-25

著者

• Yasuda Kenji

  Department Of Biomedical Information Division Of Biosystems Institute Of Biomaterials And Bioenginee

• Nomura Fumimasa

  Department Of Biomedical Information Institute Of Biomaterials And Bioengineering Tokyo Medical And

• Kaneko Tomoyuki

  Department Of Applied Physics Osaka University

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