Characteristics of High-Resolution Hemoglobin Measurement Microchip Integrated with Signal Processing Circuit
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概要
- 論文の詳細を見る
In this study, a microchip for measurement of hemoglobin in human blood has been proposed, fabricated and evaluated. The measurement principle of hemoglobin is based on the "cyanmethemoglobin method" that calculates the cyanmethemoglobin concentration by absorption photometry. A glass/silicon/silicon structure was used for the microchip. The middle silicon layer includes flow channels, and 45° mirrors formed at each end of the flow channels. Photodiodes and metal oxide semiconductor (MOS) integrated circuits were fabricated on the bottom silicon layer. The performance of the microchip for hemoglobin measurement was evaluated using a solution of red food color instead of a real blood sample. The fabricated microchip exhibited a similar performance to a nonminiaturized absorption cell which has the same optical path length. Signal processing output varied with solution concentration from 5.32 V to 5.55 V with very high stability due to differential signal processing.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2004-04-15
著者
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TAKAO Hidekuni
Toyohashi University of Technology
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SAWADA Kazuaki
Toyohashi University of Technology
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ISHIDA Makoto
Toyohashi University of Technology
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NODA Toshihiko
Toyohashi University of Technology, Department of Electrical and Electronic Engineering
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ASHIKI Mitsuaki
Toyohashi University of Technology, Department of Electrical and Electronic Engineering
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Ebi Hiroyuki
Horiba Ltd. Fundamental Technology Research Department
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Noda Toshihiko
Toyohashi University of Technology, Department of Electrical and Electronic Engineering, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan
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Sawada Kazuaki
Toyohashi University of Technology, Department of Electrical and Electronic Engineering, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan
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Ebi Hiroyuki
HORIBA Ltd., Fundamental Technology Research Department, 2 Miyanohigashi, Kisshoin, Minami-ku, Kyoto 601-8510, Japan
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Takao Hidekuni
Toyohashi University of Technology, Department of Electrical and Electronic Engineering, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan
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Ashiki Mitsuaki
Toyohashi University of Technology, Department of Electrical and Electronic Engineering, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan
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