Effects and safety of 131I-metaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors: Results from a multicenter observational registry
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概要
- 論文の詳細を見る
Effective treatments for malignant neuroendocrine tumors are under development. While iodine-131 metaiodobenzylguanidine (131I-MIBG) radiotherapy has been used in the treatment of malignant neuroendocrine tumors, there are few studies evaluating its therapeutic effects and safety in a multicenter cohort. In the current study, we sought to evaluate the effects and safety of 131I-MIBG therapy for conditions including malignant pheochromocytoma and paraganglioma within a multicenter cohort. Forty-eight malignant neuroendocrine tumors (37 pheochromocytoma and 11 paraganglioma) from four centers underwent clinical 131I-MIBG radiotherapy. The tumor responses were observed before and 3 to 6 months after the 131I-MIBG radiotherapy in accordance with RECIST criteria. We also evaluated the data for any adverse effects. The four centers performed a total of 87 131I-MIBG treatments on 48 patients between January 2000 and March 2009. Of the treatments, 65 were evaluable using RECIST criteria. One partial response (PR), 40 stable disease (SD), and 9 progressive disease (PD) in malignant pheochromocytoma were observed after each treatment. Fourteen SD and one PD were observed in paraganglioma. Patients with normal hypertension (systolic blood pressure (BP) > 130 mmHg) showed significantly reduced systolic BP after the initial follow-up (n=10, 138.1±8.2 to 129.5±13.5 mmHg, P=0.03). In adult neuroendocrine tumors with a treatment-basis analysis, there were side effects following 41 treatments (47.1%) and most of them (90.2%) were minor. In this multicenter registry, PR or SD was achieved in 84.6% of the treatment occasions in adult neuroendocrine tumors through 131I-MIBG radiotherapy. This indicated that most of the 131I-MIBG radiotherapy was performed safely without significant side effects.
- 一般社団法人 日本内分泌学会の論文
著者
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FUKUOKA Makoto
Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences
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Kayano Daiki
Department Of Nuclear Medicine Kanazawa University Hospital
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SHIGA Tohru
Department of Molecular Imaging, Hokkaido University Graduate School of Medicine
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Kinuya Seigo
Department Of Biotracer Medicine Kanazawa University Graduate School Of Medical Sciences
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Yoshinaga Keiichiro
Department Of Cardiology Kagoshima City Medical Association Hospital
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Higuchi Tetsuya
Department Of Dermatology Tokyo Medical And Dental University School Of Medicine
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Jinguji Megumi
Department Of Radiology Kagoshima University Graduate School Of Medical And Dental Sciences
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Okamoto Shozo
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nakajo Masayuki
Department Of Neuropsychiatry And Radiology Faculty Of Medicine Kagoshima University
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Ito Yoichi
Department Of Artificial Complex Systems Engineering Hiroshima University
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Oriuchi Noboru
Department Of Diagnostic Medicine And Nuclear Medicine Gunma University Graduate School Of Medicine
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Inaki Anri
Department Of Biotracer Medicine Kanazawa University Graduate School Of Medical Sciences
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Wakabayashi Hiroshi
Department Of Biotracer Medicine Kanazawa University Graduate School Of Medical Sciences
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Nakajo Masatoyo
Department Of Radiology Graduate School Of Medical And Dental Sciences Kagoshima University
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Tomiyama Yuuki
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine
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Toratani Ayane
Department of Biotracer Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
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Nakajo Masayuki
Department of Radiology, Kagoshima University, Graduate School of Medicine, Kagoshima, Japan
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