慢性耳鳴に対する柴胡桂枝湯の効果

概要

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We used Saiko-keishi-to in an attempt to alleviate tinnitus of over 3 months' duration in 13 patients. Saiko-keishi-to was administered orally at 7.5 grams per day, divided into 3 doses, and a subjective evaluation for efficacy was performed 4 weeks thereafter. Of the 13 patients, one was rated as markedly improved,2 as improved and 2 as slightly improved. In 7 patients who had a favorable response to intravenous lidocaine,2 were rated as improved and 2 as slightly improved following Saiko-keishi-to administration.<BR>Intravenous lidocaine is effective against tinnitus by blocking the hyperirritable auditory pathway. Saiko-keishi-to acts to suppress the bursts of neurons firing in an epileptic state. We presume that Saiko-keishi-to was more effective in those patients with a good response to lidocaine because of the similar actions of both of these therapies.
耳鼻咽喉科臨床学会の論文