鼻アレルギー下鼻甲介粘膜組織内のプロスタグランディンD2の増加

概要

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We measured the contents of prostaglandin D2 (PGD2) in the nasal mucosa obtained from patients with and without allergic rhinitis to determine whether PGD2 acts as a chemical mediator of allergy. The anterior portion of the mucosa of the inferior nasal turbinates were obtained by inferior turbinectomy under local anesthesia from the patients with and without allergy at Fujita Health University Hospital. PGD2 concentration was measured by HPLC-RIA method. The average PGD2 value in patients with allergic rhinitis was 4671.0 pg/g tissue (SEM575.1) and 2537.2 pg/g tissue (SEM265.5) in patients with non-allergic rhinitis. Significantly higher levels of PGD2 were found in nasal mucosa of patients with allergic rhinitis than in those with non-allergic rhinitis. The phenomenon seems to be related to the pathogenesis of allergic rhinitis. Consequently, the control of PGD2 production may be quite useful in the treatment of allergic rhinitis.
耳鼻咽喉科臨床学会の論文