The Effect of Carbon Ion Beam Irradiation for Hypoxia-Mediated Invasion of Glioblastoma
スポンサーリンク
概要
- 論文の詳細を見る
Glioblastoma is one of the most fatal malignant tumors because of its invasiveness and radioresistance. Unfortunately photon irradiation and hypoxic condition are reported to enhance cancer cells aggressiveness respectively. The purpose of this study is to clarify the effect of carbon ion beam on invasive potential of glioblastoma cells. Relative Biological Effectiveness of A172 cells measured by the dose for 1% survival fraction was 2.22. X-irradiation and hypoxic condition promoted invasion and migration of A172 and T98G cells respectively, while carbon ion beam suppressed both the two capabilities enhanced by hypoxia. GTP-RhoA (active form) was increased by 0.5 Gy of X-irradiation. On the other hand RhoA was inactivated by 1 and 4 Gy of carbon ion beam. Carbon ion beam irradiation suppressed glioblastoma cells invasion and migration via inactivation of RhoA. Furthermore carbon ion beam also inhibited these abilities enhanced by hypoxia.
- ナノ・バイオメディカル学会の論文
著者
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Koizumi Masahiko
Department Of Electronics And Information Systems Faculty Of Systems Science And Technology Akita Pr
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Kawaguchi Naomasa
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
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Mori Seiji
Department Of Chemistry The University Of Tokyo
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Minami Kazumasa
Department Of Medical Physics And Engineering Osaka University Graduate School Of Medicine
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Matsuura Nariaki
Department Of Cardiothoracic Surgery The University Of Tokyo
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MANABE Masashi
Department of Medical Economics and Management, Osaka University Graduate School of Medicine
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MORI Seiji
Department of Functional Diagnostic Science,
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IMAIZUMI Hiromasa
Department of Medical Physics and Engineering,
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HAMADA Yoshinosuke
Department of Functional Diagnostic Science,
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NAKATANI Kana
Department of Medical Physics and Engineering,
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KAWAGUCHI Naomasa
Department of Cardiovascular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan
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MATSUURA Nariaki
Department of Functional Diagnostic Science,
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