Genetic regulation of GM2 expression in liver of mouse.
スポンサーリンク
概要
- 論文の詳細を見る
GM2 containing NeuGc was found to be a major ganglioside in the liver of most inbred strains of mouse we have examined so far. They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major ganglioside in the liver. The positive expression of GM2 (NeuGc) was demonstrated in the liver of F1, hybrids between WHT/Ht and DBA/2 mice, as one of the possible combinations. Moreover, the expression of GM2 (NeuGc) in the liver was proved to be an autosomal dominant trait by ganglioside analysis of 34 individual mice of the F2 and backcross generations. WHT/Ht mouse was demon-strated to be a recessive homozygote lacking GM2 (NeuGc) expression. During the analysis, interestingly enough, the enhanced elongation of the sugar chain in the gangliosides from GM2 (NeuGc) to GM1 (NeuGc) and GD1 was observed in the liver of F1 mice and this elongation was segregated only in half members of F2 and backcross generations.
- 社団法人 日本生化学会の論文
著者
-
Sudo Katsuko
Laboratory Animal Research Center Institute Of Medical Science University Of Tokyo
-
Otsuka Hideaki
Department Of Pharmacognosy Graduate School Biomedical Sciences Hiroshima University
-
Yamakawa Tamio
Department Of Biochemistry Faculty Of Medicine
-
Hashimoto Yasuhiro
Department Of Membrane Biochemistry Tokyo Metropolitan Institute Of Medical Science
-
Suzuki Kiyoshi
Laboratory Of Applied Biochemistry Faculty Of Agriculture University Of The Ryukyus
-
SUZUKI Akemi
Department of Chemistry, National Industrial Research Institute of Nagoya
関連論文
- Structural Revisions of Blumenol C Glucoside and Byzantionoside B
- NADH-Dependent Inhibition of Branched-Chain Fatty Acid Synthesis in Bacillus subtilis
- Reinvestigation of the Absolute Stereochemistry of Megastigmane Glucoside, Icariside B5
- Expression of the Cholera Toxin B Subunit in the Golgi Apparatus of Swiss 3T3 Cells Inhibits DNA Synthesis Induced by Basic Fibroblast Growth Factor
- Movement of individually marked Aedes albopictus females in Nagasaki, Japan.
- A major glycoprotein of Xenopus egg vitelline envelope, gp41, is a frog homolog of mammalian ZP3
- A New Megastigmane Glucoside from Phlomis spinidens
- Lignan and neolignan glucosides, and tachioside 2'-O-4"-O-methylgallate from the leaves of Glochidion rubrum
- Glycosidic constituents of the leaves of an Okinawan Leguminosae plant, Derris trifoliata Lour
- Rearranged ent-kauranes from the stems of Tricalysia dubia and their biological activities
- Tareciliosides A-G : Cycloartane Glycosides from Leaves of Tarenna gracilipes (HAY.) OHWI
- Bridelioside, a new lignan glycoside from Bridelia glauca Bl. f. balansae (Tucht.) Hatusima
- Tricalysiolide G, and Tricalysiols A and B : rearranged ent-Kaurane-Type and ent-Kaurane-Type Diterpenoids from the Leaves of Tricalysia dubia (Lindl.) Ohwi
- Radical-Scavenging Activities of New Megastigmane Glucosides from Macaranga tanarius (L.) MULL.-ARG
- Staphylionosides A-K : Megastigmane Glucosides from the Leaves of Staphylea bumalda DC.
- Terpenic and Phenolic Glycosides from Leaves of Breynia officinalis HEMSL.
- Glochidiolide, Isoglochidiolide, Acuminaminoside, and Glochidacuminosides A-D from the Leaves of Glochidion acuminatum MUELL
- Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma
- Chemical constituents of imported Rosae fructus
- Schefflerins A—G, New Triterpene Glucosides from the Leaves of Schefflera arboricola
- An aggressive course of Xp11 translocation renal cell carcinoma in a 28-year-old man
- ミミズ(Pheretima sp.)における非還元末端にグルコ-スを有する新型のNeogala系スフィンゴ糖脂質
- Bumaldosides A, B and C from the leaves of Staphylea bumalda
- Stereospecificity of hydrogen transfer by pyridine nucleotide-dpendent enoyl reductases in fatty acid synthesis : Studies with enzymes obtained from developing castor bean seeds and Chlorella vulgaris
- Triterpene Glycosides and Glucosyl Esters, and a Triterpene from the Leaves of Schefflera actinophylla
- Chemical Studies on an Endemic Philippine Plant: Sulfated Glucoside and seco-A-Ring Triterpenoids from Dillenia philippinensis
- Iridoid glucoside, (3R)-oct-1-en-3-ol glycosides, and phenylethanoid from the aerial parts of Caryopteris incana
- Chemical and biologically active constituents of Pteris multifida
- Cesdiurins I-III, steroidal saponins from Cestrum diurnum L.
- Medicinal Plants of Thailand. I Structures of Rheedeiosides A—D and cis-Entadamide A β-D-Glucopyranoside from the Seed Kernels of Entada rheedei
- Crotalionosides A—C, Three New Megastigmane Glucosides, Two New Pterocarpan Glucosides and a Chalcone C-Glucoside from the Whole Plants of Crotalaria zanzibarica
- Three new olefinic acetogenin glycosides from leaves of Staphylea bumalda DC.
- Supinaionosides A and B: Megastigmane Glucosides and Supinanitrilosides A—F: Hydroxynitrile Glucosides from the Whole Plants of Euphorbia supina RAFINESQUE
- Identification of Amino Acid Positions Involved in HLA-E Expression
- Chemical constituents of the Thai medicinal plant, Dioecrescis erythroclada (Kurz) Tirveng
- DNA Fragmentation Induced in High-Cell-Density Culture of Primary Rat Hepatocytes In an Active Process Dependent on Energy Availability, Gene Expression, and Calmdulin
- (Z)-3-Hexenyl diglycosides from Spermacoce laevis Roxb.
- An Iridoid Glucoside Dimer and a Non-glycosidic Iridoid from the Leaves of Lasianthus wallichii
- Chemical constituents from Oldenlandia corymbosa L. of Thai origin
- Megastigmane and flavone glycosides from Strophioblachia fimbricalyx Boerl.
- Leeaoside, a new megastigmane diglycoside from the leaves of Leea thorelii Gagnep
- Amplification of rfbE and fliC Genes by Polymerase Chain Reaction for Identification and Detection of Salmonella Serovar Enteritidis, Dublin and Gallinarum-Pullorum
- The Senami Wrist Supporter for patients with rheumatoid arthritis
- Glochidionionosides A-D : Megastigmane Glucosides from Leaves of Glochidion zeylanicum (GAERTN.) A. Juss
- Tareciliosides H—M: Further Cycloartane Glycosides from Leaves of Tarenna gracilipes
- Cell Wall Regeneration in Woody Protoplasts
- 5-Alkylresorcinol glucosides from the leaves of Grevillea robusta Allan Cunningham
- Megastigmane glucosides and an unusual monoterpene from the leaves of Cananga odorata var. odorata, and absolute structures of megastigmane glucosides isolated from C. odorata var. odorata and Breynia officinalis
- Elaeocarpionoside, a megastigmane glucoside from the leaves of Elaeocarpus japonicus Sieb. et Zucc.
- Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii
- Myrseguinosides A—E, Five New Glycosides from the Fruits of Myrsine seguinii
- Megastigmane Glucosides from Equisetum debile and E. diffusum
- A new iridoid glucoside from the Thai medicinal plant, Morinda elliptica Ridl
- Dolichandroside, a new phenolic triglycoside from Dolichandrone serrulata (DC.) Seem
- Acetophenone Diglycosides from Erythroxylum cambodianum
- A Streptavidin-Based Neoglycoprotein Carrying More Than 140 GT1b Oligosaccharides: Quantitative Estimation of the Binding Specificity of Murine Sialoadhesin Expressed on CHO Cells^1
- Conjugates of an abscisic acid derivative and phenolic glucosides, and a new sesquiterpene glucoside from Lindera strychnifolia
- 103. Identification of Staphylococcus carnosus strains from fermented fish and soy sauce mash
- A New Megastigmane Glucoside from Phlomis spinidens
- Malignant transformation of renal angiomyolipoma
- Gallates of isoorientin and (2S)-1,2-propanediol glucoside from the leaves of Schoepfia jasminodora
- Three New Flavonoid Glycosides, Byzantionoside B 6′-O-Sulfate and Xyloglucoside of (Z)-Hex-3-en-1-ol from Ruellia patula
- A glycerol α-D-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.
- Flavonol glycosides from the leaves of Indigofera zollingeriana
- Prenylated flavonoid glucoside and two aliphatic alcohol glycosides from the leaves of Euodia meliaefolia (Hance) Benth
- Constituents of cultivated Agaricus blazei
- Medicinal plants of Thailand (2) chemical studies on the seed kernels of Entada rheedei Sprengel
- Biochemical outcome of small-volume or insignificant prostate cancer treated with radical prostatectomy in Japanese population
- Reinvestigation of Structures of Robustasides B and C, and Isolation of (E)-2,5-Dihydroxycinnamic Acid Esters of Arbutin and Glucose from the Leaves of Grevillea robusta
- Dianthosaponins A-F, Triterpene Saponins, Flavonoid Glycoside, Aromatic Amide Glucoside and .GAMMA.-Pyrone Glucoside from Dianthus japonicus
- Medicinal plants of Thailand. II : chemical studies on the seed kernels of Entada rheedei Sprengel
- Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata
- Identification of stereoisomers of methyl hexopyranosides by mass spectrometry of their trifluoroacetates.
- Structures of Ryobunins A–C from the Leaves of Clethra barbinervis
- Genetic regulation of GM2 expression in liver of mouse.