Synergistic Effect of Proanthocyanidin on the Bactericidal Action of the Photolysis of H<SUB>2</SUB>O<SUB>2</SUB>
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概要
- 論文の詳細を見る
The <I>in vitro</I> antibacterial activity of the hydroxyl radical generation system by the photolysis of H<SUB>2</SUB>O<SUB>2</SUB> in combination with proanthocyanidin, which refers to a group of polyphenolic compounds, was examined. Bactericidal activity of photo-irradiated H<SUB>2</SUB>O<SUB>2</SUB> at 405 nm against <I>Streptococcus mutans</I>, a major pathogen of dental caries, was augmented in the presence of proanthocyanidin, whose bactericidal effect by itself was very poor, in a concentration-dependent manner. This combination was also proven effective against <I>Porphyromonas gingivalis</I>, a major pathogen of periodontitis. It is speculated that H<SUB>2</SUB>O<SUB>2</SUB>, generated from photo-irradiated proanthocyanidin around the bacterial cells, is photolyzed to the hydroxyl radical, which would in turn affect the membrane structure and function of the bacterial cells, resulting in augmented sensitivity of bacterial cells to the disinfection system utilizing the photolysis of H<SUB>2</SUB>O<SUB>2</SUB>. The present study suggests that the combination of H<SUB>2</SUB>O<SUB>2</SUB> and proanthocyanidin works synergistically to kill bacteria when photo-irradiated.
- 日本防菌防黴学会の論文
著者
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Niwano Yoshimi
Tohoku University Graduate School Of Dentistry
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NAKAMURA Keisuke
Tohoku University Graduate School of Dentistry
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KANNO Taro
Tohoku University Graduate School of Dentistry
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SASAKI Keiichi
Tohoku University Graduate School of Dentistry
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IKAI HIROYO
Tohoku University Graduate School of Dentistry
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SHIRATO MIDORI
Tohoku University Graduate School of Dentistry
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MEIRELLES LUIZ
Eastman Institute for Oral Health, University of Rochester
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