Prophylactic Statin Administration May Prevent Shortening of the Fibrillation Cycle Length in Patients With New-Onset Atrial Fibrillation
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概要
- 論文の詳細を見る
Patients with recently diagnosed atrial fi brillation (AF) tend to exhibit a longer fi brillation cycle length (FCL) than those having a longer clinical history. However, the electrophysiological properties of new-onset AF may vary because of the clinical background of patients. In this study, we evaluated clinical factors to identify the determinants of FCL in new-onset AF. Electrocardiograms (ECGs) recorded from 2008 through 2011 were analyzed using our digital ECG-profi ling system. In the 1,578 AF episodes recorded, 466 new-onset AF episodes were identifi ed using clinical referral history and previous ECGs. After evaluating FCL in these new-onset AF episodes, using a customized fibrillation wave analyzer with fast Fourier transform analysis, we divided the patients into a longer-FCL group and a shorter-FCL group using the median FCL (158 ms). Propensity score matching yielded 135 matched pairs of patients with comparable mean ages between the two groups. Four factors (brain natriuretic peptide levels, and use of angiotensin receptor blockers, calcium channel blockers or statins) exhibited a significant difference between the two groups. Multivariate analysis revealed that statin use was the only significant independent predictor of longer FCL (Odds ratio, 3.86; 95% CI, 1.659.63; <I>P</I> = 0.003). Among various clinical parameters, statin use was related to longer FCL at the time of new-onset AF in patients with AF.
- International Heart Journal刊行会の論文
著者
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Fukaya Hidehira
Department of Cardio-angiology, Kitasato University School of Medicine
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Niwano Hiroe
Department Of Cardio-angiology Kitasato University School Of Medicine
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Fukaya Hidehira
Department Of Cardio-angiology Kitasato University School Of Medicine
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Hatakeyama Yuko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Kurokawa Sayaka
Department Of Cardio-angiology Kitasato University School Of Medicine
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Satoh Akira
Department Of Applied Biochemistry Faculty Of Applied Biological Science Hiroshima University
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Oikawa Jun
Department of Cardio-Angiology, Kitasato University School of Medicine
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Ishizue Naruya
Department of Cardio-Angiology, Kitasato University School of Medicine
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Yoshizawa Tomoharu
Department of Cardio-Angiology, Kitasato University School of Medicine
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Fukaya Hidehira
Department of Angio-Cardiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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Niwano Hiroe
Department of Education, Tamagawa University, College of Education
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