Relationship between Hyperuricemia and Hyperinsulinemia

概要

論文の詳細を見る
Objective: The purpose of this retrospective cohort study was to evaluate an association between hyperuricemia and plasma glucose (PG) and immunoreactive insulin (IRI) during a 75 g oral glucose tolerance test (OGTT) in subjects with normal and borderline OGTT patterns. Methods: Out of 1175 subjects who underwent the OGTT, 1007 with normal or borderline OGTT patterns were enrolled in the present study. The enrolled subjects were divided into 2 groups: high uric acid (UA) level group with UA > 7.0mg/dl; normal UA level group with UA ≤ 7.0mg/dl. They were also classified into 25,50,75 and 100 percentiles.Results: High UA group had a higher plasma IRI response pattern; High UA group had higher rate of fatty liver than normal UA group; Subjects in high UA group had higher rate of delayed IRI response pattern than subjects in normal UA group.Conclusion: The present study indicates a relationship between hyperuricemia and hyperinsulinemia.