腎機能からみたC型慢性肝炎に対するペグインターフェロンα-2b/リバビリン/テラプレビル三剤併用療法における貧血の予測

概要

論文の詳細を見る
Anemia is one of the most important side effects in triple therapy, and it is known that ribavirin-induced anemia is enhanced by telaprevir-induced renal dysfunction. Therefore, we investigated the relationship between hemoglobin (Hb) levels and the estimated glomerular filtration rate (eGFR). Hb levels showed a transient increase at 3 days, then gradually decreased until achieving nadir at 12 weeks. Conversely, eGFR achieved nadir at 3 days. A Hb level of <10 g/dL at 12 weeks was significantly associated with eGFR at 3 days, and the cut-off value was 60 mL/min/1.73 m2. An eGFR of <60 mL/min/1.73 m2 at 3 days was significantly associated with eGFR at baseline, and the cut-off value was 80 mL/min/1.73 m2. eGFR may be a useful clinical parameter for protecting against severe anemia.