Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide–Receptor Activation in Rats With Spinal Nerve Injury–Induced Neuropathy
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概要
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We evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20, μg/kg, exhibited naloxone-reversible analgesic activity in naïve rats. In contrast, buprenorphine at 0.5 - 20 μg/kg produced a naloxone-sensitive antihyperalgesic effect in the L5 spinal nerve-injured neuropathic rats. Intrathecal injection of [N-Phe1]nociceptin(1-13)NH2, a NOP-receptor antagonist, reversed the effect of buprenorphine in neuropathic rats, but not in naïve rats. Together, buprenorphine suppresses neuropathic hyperalgesia by activating NOP and opioid receptors, suggesting its therapeutic usefulness in treatment of neuropathic pain.
- 公益社団法人 日本薬理学会の論文
著者
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Takemura Motohide
Department Of Oral Anatomy And Neurobiology Osaka University Graduate School Of Dentistry
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Sekiguchi Fumiko
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Nishikawa Hiroyuki
Division Of Breast And Endocrine Surgery St. Marianna University Hospital
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Takahashi Tomoko
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Tsubota-Matsunami Maho
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy
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Kawabata Atsufumi
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Okubo Kazumasa
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Kojima Shota
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Tsubota-Matsunami Maho
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Kojima Shota
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Okubo Kazumasa
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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Takemura Motohide
Department of Oral Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, Japan
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Takahashi Tomoko
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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