Colonic Hydrogen Sulfide–Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Ca<SUB>v</SUB>3.2 and TRPA1 Channels in Mice
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概要
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Luminal hydrogen sulfide (H<SUB>2</SUB>S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca<SUP>2+</SUP> channels. Here we analyzed the mechanisms for H<SUB>2</SUB>S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H<SUB>2</SUB>S donor, evoked visceral pain−like nociceptive behavior and referred hyperalgesia in mice, an effect abolished by NNC 55-0396, a selective T-type Ca<SUP>2+</SUP>-channel blocker, or by knockdown of Ca<SUB>v</SUB>3.2. AP18, a TRPA1 blocker, also prevented the NaHS-induced colonic pain and referred hyperalgesia. These findings demonstrate that H<SUB>2</SUB>S-induced colonic pain and referred hyperalgesia require activation of both Ca<SUB>v</SUB>3.2 and TRPA1 channels in mice.
- 公益社団法人 日本薬理学会の論文
著者
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Kawabata Atsufumi
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Sekiguchi Fumiko
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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NOGUCHI Yumi
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy
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Okawa Yasumasa
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Tsubota-Matsunami Maho
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan
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Tsubota Matsunami
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Noguchi Yumi
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Kawabata Atsufumi
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan
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Sekiguchi Fumiko
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan
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- Colonic Hydrogen Sulfide-Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Ca_v3.2 and TRPA1 Channels in Mice
- Colonic Hydrogen Sulfide–Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Cav3.2 and TRPA1 Channels in Mice
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