Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle
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概要
- 論文の詳細を見る
We investigated the effects of NaHS, an H2S donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 – 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 – 3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system.
- 社団法人 日本薬理学会の論文
- 2007-08-20
著者
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KAWABATA Atsufumi
Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University
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Kawabata Atsufumi
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Kubo Satoko
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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DOE Ichiko
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy
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KUROKAWA Yuko
Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy
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Kawabata Atsufumi
Div. Of Pharmacology And Pathophysiology Kinki Univ. School Of Pharmacy Jpn
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Kurokawa Yuko
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Doe Ichiko
Division Of Pharmacology And Pathophysiology Kinki University School Of Pharmacy
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Kawabata Atsufumi
Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan
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