Regulation of Lipid Metabolism and Modified Enzyme

概要

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It was demonstrated that lipases in both liver and adipose tissue consist of a complex of esterase and lipid. When a clearing factor of rat serum was subjected to DEAE-cellulose column chromatography, it was easily converted to esterase. Rat liver mitochondria contained two kinds of acyl CoA synthetase, a long chain acyl CoA synthetase and a middle chain acyl CoA synthetase, which were separated by gel filtration on Sephadex G-200 column. When the long chain acyl CoA synthetase was treated with Triton-X 100, the enzyme was partly converted into middle chain acyl CoA synthetase.<BR>The results suggest that these enzymes, lipases in liver and adipose tissue, a clearing factor and acyl CoA synthetase, are modified in various ways in cells and such modifications might have relation to their physiological significance. Therefore, we would like to name these modified enzymes.<BR>Our definition of a modified enzyme is as follows: a modified enzyme is such one in which a certain modifier combines with an enzyme, resulting in appearance of a new physiological function.
Japan Society of Clinical Chemistryの論文