Relationship between Acetate Metabolism and Glycolysis in Mammary Gland Slices of Normal, Starved and Alloxan Diabetic Sheep

概要

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In sheep, large amounts of acetate are produced in the rumen, where they are absorbed, and then transported to the mammary gland for metabolism. The following results were obtained in a study on influences of glucose and its metabolites on the acetate metabolism in the mammary gland slices of normally fed, starved and alloxan diabetic sheep. 1) Consumption of acetate and formation of CO2 and lipid from acetate showed a decrease following starvation and alloxan treatment. 2) In normal and starved sheep, acetate consumption and formation of CO2 and lipid from acetate showed an increase following the addition of glucose and phosphoenolpyruvate. These effects of glucose and phosphoenolpyruvate on the acetate metabolism disappeared following treatment with alloxan. 3) In normal, starvied and alloxan diabetic sheep, the addition of pyruvate and lactate did not influence the acetate metabolism. From these results it may be deduced that there was some relationship between the acetate metabolism and the glucose-phosphoenolpyruvate system, and insulin had some role in the action of the glucose-phosphoenolpyruvate system on the acetate metabolism.
Japan Society of Clinical Chemistryの論文