Relationship between Acetate Metabolism and TCA cycle in Mammary Gland Slices of Normal, Starved and Alloxan Diabetic Sheep
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概要
- 論文の詳細を見る
It was reported that starvation and alloxan treatment influenced the acetate metabolism in mammary gland slices of sheep, and relationships between the acetate metabolism and glycolisis changed following starvation and alloxan treatment. Further study was designed to elucidate the relationships between the acetate metabolism and TCA cycle, and how the relationships were influenced by starvation and alloxan treatment. The following results were obtained in a study of the influence of citrate or succinate on the <SUP>14</SUP>C-acetate metabolism and those of acetate on the metabolism of <SUP>14</SUP>C-citrate or-succinate in mammary gland slices of normally fed, starved and alloxan diabetic sheep.<BR>In normal and starved condition, the <SUP>14</SUP>C-acetate consumption and the <SUP>14</SUP>C transfer from <SUP>14</SUP>C-acetate into CO<SUB>2</SUB> and lipid increased by the addition of citrate and succinate. The <SUP>14</SUP>C-citrate consumption and the <SUP>14</SUP>C transfer into CO<SUB>2</SUB> and lipid decreased by the acetate addition, and the <SUP>14</SUP>C-succinate consumption and the <SUP>14</SUP>C tranfer from <SUP>14</SUP>C-succinate into CO<SUB>2</SUB> and lipid increased by the acetate addition in normal and starved sheep. Effects of citrate and succinate on the acetate metabolism and those of acetate on the metabolism of citrate or succinate in starved condition were larger than the case of normal condition. Effect of citrate on the acetate metabolism and those of acetate on the citrate metabolism disappeared following treatment. But effects of succinate on the acetate metabolism and those of acetate on the succinate metabolism were observed in alloxan diabetes.<BR>As mentioned above, there were some relationships between the acetate metabolism and the metabolism of citrate and succinate, and this relationships changed due to starvation and alloxan treatment.
- Japan Society of Clinical Chemistryの論文
著者
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川上 正澄
横浜市立大・第二生理
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竹島 三知子
神奈川県総合リハビリテーションセンター生化学研究室
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瀬戸 勝男
神奈川県総合リハビリテーションセンター生化学研究室
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BLACK ARTHUR
カリフォルニア大学生理科学科
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