Relationship between Butyrate Metabolism and Glycolysis in Liver Slices of Normal, Starved and Alloxan Diabetic Sheep

概要

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It was reported that glucose showed various effects on the butyrate metabolism in sheep liver slices and these effects were changed by alloxan treatment. Presently a report was made of influences of glucose metabolites upon the butyrate metabolism in liver slices of normal, starved and, alloxan diabetic sheep. The experimental results were summarized as follows: 1) In normal and starved sheep, the 14C transfer from 14C-butyrate into glucose and NEFA was decreased by the addition of phosphoenolpyruvate and the formaion of 14C-cholesterol, -triglycerides and-phospholipid from 14C-butyrate was increased by the addition of phosphoenolpyruvate. These effects of phos phoenolpyruvate on the butyrate metabolism disappeared following treatment with alloxan. 2) In starvation the 14CO2 formation from 14C-butyrate was increased by the addtion of phosphoenolpyruvate. But there were no effects of phosphoenolpyruvate addition on the formation of 14CO2 from 14C-butyrate in normal and alloxan diabetes sheep. 3) Normal, starved, and alloxan diabetic sheep, showed no effects of phosphoenolpyruvate addition on the 14C transfer from 14C-butyrate into ketone bodies. 4) In normal, starved and alloxan diabetic sheep, the addition of pyruvate and lactate did not influence the 14C transfer from 14Cbutyrate into CO2, glucose, ketone bodies and all lipid fractions.
Japan Society of Clinical Chemistryの論文