Relationship between Acetate Metabolism and TCA cycle in Liver Slices of Normal,Starved and Alloxan Diabetic Sheep

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It was reported that starvation and alloxan treatment influenced the acetate metabolism in sheep liver slices, and relationships between the acetate metabolism and glycolisis changed following alloxan treatment. Further study was designed to elucidiate the relationships between the acetate metabolism and TCA cycle, and how the relationships were influenced by starvation and alloxan treatment. The following results were obtained in a study of the influence of citrate or succinate on the 14C-acetate metabolism and of acetate on the metabolism of 14C-citrate or-succinate in liver slices of normalily fed, starved and alloxan diabetic sheep. In normal and starved conditions, transfer of 14C from 14C-acetate into CO2, cholesterol, triglyceride and phospholipid increased and the formation of 14C-glucose, -ketone bodies and NEFA from 14C-acetate decreasad by the addition of citrate or succinate. The formation of 14CO from 14C-citrate or-succinate increased and transfer of 14C from 14C-citrate or-succinate into glucose, ketone bodies, cholesterol, triglyceride and phospholipid decreased by the addition of acetate in nlrmal and starved sheep. Effects of citrate on the acetate metabolism and those of acetate on the citrate metabolism disappeared following alloxan treatmet. But effects of succinate on the acetate metabolism were observed in alloxan diabetes. As mentilned above, citrate or succinate showed various effects on the acetate metabolism and also the acetate had various effects on the metabolism of citrate and succinate. The relationships betweentheacetate and succinate metabolisms changed due to alloxan treatment.
Japan Society of Clinical Chemistryの論文

Relationship between Acetate Metabolism and TCA cycle in Liver Slices of Normal,Starved and Alloxan Diabetic Sheep

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