Hyperlipemia in Pregnancy

概要

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Normal ranges of meternal lipid concentration in 10 months pregnancy and at delivery are 210-300mg/dl of total cholesterol, 280-400mg/dl of phospholipids, 160-400mg/dl of triglycerides. The frequency of hyperlipemia is 31.3% and hypolipemia is also 21.2% of whole pregnant women. The 72.7% of toxemic pregnant women are in hyperlipemia, and there is no case in hypolipemia. Hypertriglyceridemia is specially significant in toxemic cases. In atempt to know the mechanism of hyperlipemia during pregnancy, the studies onthe rate of elimination from the blood stream of injected fat emulsion "Intralipid" and measurement of LPL activity were done in non-pregnant and pregnant women. It is characteristic in pregnancy that the high concentration of endogeneous and exogeneous TG at fasting time and low K2 value (elimination rate from blood stream of "Intralipid"). The activity of lipoprotein lipase of post heparin plasma in pregnant women is significantry decteased and is about 1/3 of non-pregnant cases. It was discussed that the clinical observation and the reason for the hyperlipemia in pregnancy.
Japan Society of Clinical Chemistryの論文