Aggregation and Fibrillation Study of α-synuclein Under Applied Voltage
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概要
- 論文の詳細を見る
The application of voltage has been used to control the movement of charged molecule such as DNA, some proteins and phospholipid in recent year. In this study, we first applied voltage to amyloidogenic protein, α-synuclein, which is related to Parkinson's disease. To offer the new approach using electric field and new insight into aggregation and fibrillation mechanism of α-synuclein, we tried to control the aggregation of α-synuclein, which has a negative charge, by applying voltage to it. The aggregation of α-synuclein without conformational change occurred rapidly when a voltage of 1 V was applied. The protein did not form amyloid-like fibrils, but it did form small aggregates. These results demonstrate that this technique might be useful not only to efficiently control aggregation of α-syn but also to understand the mechanism of aggregation and fibrillation of α-syn.
- 公益社団法人 電気化学会の論文
著者
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HAN SungWoong
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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Han Sungwoong
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
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Sode Koji
Department Of Biotechnology And Life Science Faculty Of Engineering Tokyo University Of Agriculture
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Nakamura Chikashi
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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Ikebukuro Kazunori
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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Nakamura Chikashi
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology:biomedic
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Ikebukuro Kazunori
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
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OSAWA Yuko
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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KOBAYASHI Natsuki
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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SODE Koji
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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