Corticosteroids Were Effective for Preventing Immidiate Atrial Fibrillation Events in Patients with Pericardial Effusion Due to the Ablation

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Background: Inflammatory responses caused by pericardial effusion during atrial fibrillation (AF) ablation contribute to the risk for immediate AF events and we bother in a dilemma between discontinuance of anticoagulation therapy to stop bleeding and thromboembolic risk due to AF. Therefore, we investigated the efficacy of anti-inflammatory drugs in preventing AF events after cardiac perforation. Methods: A total of 21 patients with a periprocedural pericardial effusion were included. We compared occurrence of immediate AF events in patients used oral NSAIDs only or NSAIDs and intravenous sodium methylprednisolone succinate given on the day of the procedure. Results: Foueteen (66.7%) patients experienced immediate AF events and 7 patients maintained sinus rhythm. The maximum CRP level was 7.6±5.7 mg/dl in patients with AF events and 3.2±3.9 mg/dl in those without. AF events occurred in 78.5% of patients used NSAIDs only and in 21.4% of patients used NSAIDs and corticosteroids. The maximum CRP level in patients used NSAIDs only was 7.9±5.6 mg/dl, as opposed to 1.9±1.3 mg/dl in those used NSAIDs and corticosteroids. Conclusion: The use of corticosteroids for pericardial effusion due to the AF ablation maybe effective for preventing immediate AF events.