RT, RTend and Tpeak-End Intervalby Signal-Averaged Vector 187 Channel High Resolution ECG for Risk Stratification of Brugada Syndrome

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Spatial and transmural dispersion of refractoriness have been reported to relate to arrhythmogenesis of Brugada syndrome (BS). Recovery time (RT), RTend and Tpeak-end (Tp-e) was evaluated in Brugada syndrome (BS). The synthesized signals from vector-projected 187-channel ECGs were amplified. Maximum inter-lead difference, mean inter-lead difference of RT, max. and avg. RT, max. and avg. RTend, max. and avg. Tp-e interval, and late potential by vector magnitude ECG were compared were studied in 27 spontaneous type 1 ECG and 14 non-type 1 BS patients. There were no significant differences in max. and avg. RTend interval, max. Tp-e interval, and avg. RT between type 1 and non-type 1 patients. But max. RT was marginally longer in type 1 patients (86.3±20.8 vs. 73.7±20.9 ms, P=0.07). No relation was found between max. and avg. RT and RTend, and max. Tpeak-end to the symptom. However, avg. Tp-e interval was significantly longer in patients with than that in patients without symptom (41.1±15.2 ms vs. 27.6±13.7 ms, P=0.028). Late potentials were positive in 87.5% (7/8) in 8 patients with symptom, and in 50% (16/32) in patients without symptom P=0.1074). <B>Conclusions:</B> Spatial dispersion of repolarization may relate to the typical ECG manifestation of BS and not spatial and transmural dispersion of repolarization but conduction disturbance may relate to the arrhythmic events.
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