Combined Assessment of Myocardial Perfusion and Function by ECG-Gated Myocardial Perfusion Single-Photon Emission Computed Tomography for the Prediction of Future Cardiac Events in Patients With Type 2 Diabetes Mellitus
スポンサーリンク
概要
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Background: The mid-term prognostic significance of ECG-gated single-photon emission computed tomography (SPECT) remains unclear in Japanese patients with type 2 diabetes mellitus (DM). In the present study rates of future cardiac events (nonfatal acute myocardial infarction (AMI), cardiac death (CD) and severe heart failure (HF) requiring hospitalization) were compared in patients with and without DM. Methods and Results: 1,810 patients (563 DM and 1,247 non-DM) we followed for a mean of 26.3±15.5 months. Summed stress score (SSS), summed difference score (SDS), poststress ejection fraction (EF) and resting end-diastolic volume (EDV) were calculated. In total, 20 cases of AMI (9 in DM (1.59%) and 11 in non-DM (0.88%)), 20 of CD (7 in DM patients (1.24%) and 13 in non-DM (1.04%)) and 54 of severe HF (31 in DM (5.5%) and 23 in non-DM (1.84%)) occurred. Univariate Cox analysis showed that, in DM patients, predictors of total cardiac events were poststress EF (Wald 60.4; P<0.001), resting EDV (Wald 53.8; P<0.001), SSS (Wald 39.6; P<0.001), SDS (Wald 26.1; P<0.001), history of prior MI (Wald 4.32; P<0.05) and hemoglobin A1c value (Wald 4.30; P<0.05). Multivariate Cox analysis showed that poststress EF (Wald 9.85; P<0.01) and SDS (Wald 6.19; P<0.01) were independent predictors of total cardiac events. Conclusions: Combined assessment of perfusion and function by ECG-gated SPECT may predict future cardiac events in type 2 DM patients. (Circ J 2011; 75: 376-382)
- 2011-01-25
著者
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HIRAYAMA Atsushi
Osaka Police Hospital
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HIRAYAMA Atsushi
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Matsumoto Naoya
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Nagao Ken
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Sato Yuichi
Department of Imaging, Health Park Clinic Kurosawa
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Hirayama Atsushi
Division Of Cardiovascular Medicine Department Of Medicine Nihon University School Of Medicine
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Sawa Yoshiki
Department Of Cardiovascular Surgery Osaka Graduate School Of Medicine
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Sato Y
Department Of Cardiology Kawaguchi Municipal Medical Center
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Hirayama A
Division Of Cardiovascular Medicine Department Of Medicine Nihon University School Of Medicine
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Sato Yuichi
日本大学 医学部循環器内科学
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KASAMA Shu
Department of Vascular Medicine, Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular
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Sugino K
Department Of Cardiology Amagasaki Central Hospital
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Kasama Shu
Department Of Cardiovascular Medicine Gunma University School Of Medicine
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Katoh Masahiko
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kofune Masayoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Yoda Shunichi
Division of Cardiovascular Medicine, Nihon University School of Medicine
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Hirata Akio
大阪警察病院 心臓セ
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Yoda S
Department Of Advanced Medicine Nihon University School Of Medicine
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Yokoyama Shin-ichiro
昭和大学藤が丘病院 循環器内科
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Yokoyama Shinichiro
Second Department Of Internal Medicine Nihon University School Of Medicine
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Matsumoto Naoya
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Komatsu Sei
Cardiovascular Division Amagasaki Chuou Hospital
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Nagao Ken
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kajiwara Nagao
Dept. Of Cardiology Surugadal Nihon University Hospital
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Kato M
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Yoda S
Department Of Cardiology Nihon University Surugadai Hospital
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Yokoyama Sin-ichiro
Department Of Advanced Medicine Nihon University School Of Medicine
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Suzuki Yasuyuki
Division of Cardiovascular Medicine, Toyohashi Heart Center
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Hirayama Atsushi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Hirayama Atsushi
日本大学 医学部内科学系循環器内科
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Kato Masahiko
Division of Cardiovascular Medicine, Department of Internal Medicine, Tottori University Faculty of
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Hanatani Akihisa
国立循環器病研究センター 心臓血管内科部門
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Akamatsu Hiroki
Department Of Cardiology Nihon University Surugadai Hospital
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Sato Yuichi
Department Of Imaging Health Park Clinic Kurosawa
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Nakano Yoshimochi
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Sato Yoichi
The Dep. Of Cardiology Surugadai Nihon Univ. Hospital
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Sawa Yoshiki
Department Of Surgery Osaka University Graduate School Of Medicine
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Nagao Ken
SOS-KANTO Investigators
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Suemoto Yoshinobu
Department Of Cardiology Kawaguchi Municipal Medical Center
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Abeta Hiromi
Department Of Cardiology Surugadai Nihon University Hospital
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Hirayama Atsushi
Department Of Cardiology Nihon University School Of Medicine
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Nakano Yoshimochi
Department Of Cardiology Nihon University Surugadai Hospital
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Seino Yoshihiko
First Department Of Internal Medicine Nippon Medical School
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Yokoyama Shinichiro
Department Of Cardiology Nihon University School Of Medicine
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Suzuki Y
Protect (prospective Trial Of Cardioprotective Effect Of Carperitide Treatment) Study Group
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Suzuki Yasuyuki
Department Of Cardiology Nihon University Surugadai Hospital
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Yoda Shunichi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Yokoyama Shin-ichiro
Second Department Of Internal Medicine Nihon University School Of Medicine
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Nagao Ken
Tokyo Coronary Care Unit Network
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Yoda Shunichi
Division Of Cardiology Nihon University School Of Medicine
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Suzuki Yasushi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Satoh Yohichi
Department Of Cardiology Surugadai Nihon University Hospital
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Yokoyama Shinichiro
Department Of Medicine Division Of Cardiovascular Medicine Nihon University School Of Medicine
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Sugino Keiichi
Department Of Cardiology Surugadai Nihon University Hospital
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Komoriya Masakazu
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Nagao Ken
Department Of Emergency And Critical Care Medicine Surugadai Nihon University Hospital
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Nakano Yoshimochi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Suzuki Yasuyuki
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Yokoyama Shin-ichiro
Department Of Advanced Medicine Nihon University School Of Medicine
-
Hirayama Atsushi
Division Of Cardiology Department Of Internal Medicine Nihon University School Of Medicine
-
Sato Yoshiyuki
Department Of Cardiology Nihon Univeristy School Of Medicine
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Aoyama Hiroshi
Department Of Cardiology Surugadai Nihon University Hospital
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Satoh Yoshihiro
Department Of Cardiology Kawaguchi Municipal Medical Center
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Sawa Yoshiki
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Selno Yoshihiko
Division Of Ccu And Icu Nippon Medical School
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Sato Yuichi
Department Of Cardiology Suruga-dai Nihon University Hospital
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Sawa Yoshiki
Department Of Cardiovascular Surgery
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Sawa Yoshiki
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Sato Yuichi
Department Of Applied Tumor Pathology Kitasato University Graduate School Of Medical Sciences
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Shirakawa Yukitoshi
Department Of Cardiovascular Surgery Osaka University Graduate School Of Medicine
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Sato Yuichi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Sato Yoshiyuki
Department Of Pediatrics School Of Medicine Nihon University
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Matumoto Naoya
Department Of Cardiology Nihon University School Of Medicine
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Nagao Ken
Department Of Cardiology Surugadai Nihon University Hospital
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Kajiwara Nagao
Dept. Of Cardiovas. Dis. Surugadai Hosp. School Of Med.
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Nagao Ken
Department Of Cardiology Resuscitation And Emergency Cardiovascular Care Surugadai Nihon University
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Kujiwara Nagao
Department Of Cardiology Surugadai Nihon University Hospital.
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Hirayama Atushi
Department Of Cardiology Nihon University School Of Medicine
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