Prolonged QRS Duration in Lead V2 and Risk of Life-Threatening Ventricular Arrhythmia in Patients With Brugada Syndrome
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概要
- 論文の詳細を見る
Brugada syndrome is an inherited disorder that predisposes some patients to sudden cardiac death. It is not well established which Brugada syndrome patients are at risk of life-threatening arrhythmias. We investigated whether standard 12-lead electrocardiograms (ECG) can identify such patients. The subjects were 35 men with Brugada syndrome (mean age, 50.1 ± 12.4 years). Documented ventricular fibrillation or aborted sudden cardiac arrests were judged to be related to the Brugada syndrome. Ten patients (mean age, 49.6 ± 14.9 years) were symptomatic, and 25 (mean age, 50.3 ± 11.5 years) were asymptomatic. We determined the PR interval, QRS duration, and QT interval from baseline 12-lead ECG leads II and V2 as well as the J point elevation amplitude of lead V2. The QRS interval was measured from QRS onset to the J point in leads II and V2. The only significant difference between the symptomatic and asymptomatic patients was the QRS duration measured from lead V2. The mean QRS interval was 129.0 ± 23.9 ms in symptomatic patients versus 108.3 ± 15.9 ms in asymptomatic patients (P = 0.012). A QRS interval in lead V2 ≥ 120 ms was found to be a possible predictor of a life-threatening ventricular arrhythmia and/or syncope (P = 0.012). Prolonged QRS duration as measured on a standard 12-lead ECG is associated with ventricular arrhythmia and could serve as a simple noninvasive marker of vulnerability to life-threatening cardiac events in patients with Brugada syndrome.
著者
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Kofune Masayoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Watanabe Ichiro
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kasamaki Yuji
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kunimoto Satoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Ashino Sonoko
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Nagashima Koichi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kofune Tatsuya
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Okumura Yasuo
Division Of Cardiology Department Of Cardiovascular Disease Nihon University School Of Medicine
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Nakai Toshiko
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Ohkubo Kimie
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Hirayama Atsushi
Division Of Cardiology Department Of Internal Medicine Nihon University School Of Medicine
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