Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy
スポンサーリンク
概要
- 論文の詳細を見る
Carcinomatous meningitis (CM) is a severe complication of lung cancer. Here, we report on two EGFR-mutated patients who attained relatively long survivals by erlotinib treatment after diagnosis of CM. The first case is a 59-year-old woman who was diagnosed as adenocarcinoma harboring an EGFR mutation (L858R); her disease was at stage IV with multiple brain metastases. The time from the initial diagnosis of lung cancer to CM was 364 days. Erlotinib was administered for 5 months, and the survival time from the diagnosis of CM was 278 days. The second case is a 60-year-old man who underwent right lower lobe lobectomy and was diagnosed as adenocarcinoma with an EGFR mutation (E746-750 deletion) and at the pathological stage IIA (pT1N2M0). Later, the disease was recurring as brain metastasis, and progressed to CM 637 days after diagnosis of lung cancer. Erlotinib was administered for 5.5 months, and the survival time from the diagnosis of CM was 281 days. These cases indicate that erlotinib is a reasonable option for the treatment of CM in EGFR-mutated patients.
著者
-
Okano Tetsuya
Department Of Internal Medicine Division Of Pulmonary Medicine Infectious Diseases And Oncology Nipp
-
Uchida Yuka
Department Of Respiratory Medicine Saitama Medical University
-
Nagai Yoshiaki
Department Of Electrical Engineering Faculty Of Technology Kanazawa University
-
Koyama Nobuyuki
Department Of Respiratory Medicine Saitama Medical University
-
Murayama Yoshitake
Department Of Respiratory Medicine Saitama Medical University
-
Kobayashi Kunihiko
Department Of Agricultural Chemistry Faculty Of Agriclture Yamaguchi University
-
Okano Tetsuya
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Ishikawa Rinako
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Kaga Akiko
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Utsugi Harue
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Mio Tomohiko
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Daito Hisayoshi
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Maeno Yuri
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Kotajima Futoshi
Emergency Department, Saitama Medical University International Medical Center
-
Sakaguchi Hirozou
Department of Thoracic Surgery, Saitama Medical University International Medical Center
-
Kaga Akiko
Department of Respiratory Medicine, Saitama Medical University
-
Koyama Nobuyuki
Department of Respiratory Medicine, Saitama Medical University International Medical Center
-
Uchida Yuka
Department of Respiratory Medicine, Saitama Medical University International Medical Center
関連論文
- Ehlers-Danlos Syndrome Type IV, Vascular Type, Which Demonstrated a Novel Point Mutation in the COL3A1 Gene
- Early diagnosis for polyarthritis of juvenile idiopathic arthritis using systemic gallium scintigraphy
- Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21^ expression
- Heat-induced Aggregation between Ovalbumin and Lysozyme(Food & Nutrition)
- Elevated serum levels of soluble interleukin-2 receptor in juvenile dermatomyositis
- Conformational Changes and Functional Properties of Acid-modified Soy Protein
- Changes in the Emulsifying and Foaming Properties of Proteins during Heat Denaturation
- Determination of Molecular Weight of Soluble Ovalbumin Aggregates during Heat Denaturation Using Low Angle Laser Light Scattering Technique
- Impairment of myocardial flow reserve and endothelial function even in apparently normal coronary regions after Kawasaki disease using 15O-water PET
- Phase I studies of nogitecan hydrochloride for Japanese
- Mild immunoglobulin A nephropathy in a patient with a marked increase in serum immunoglobulin A
- Functional Casein-Polysaccharide Conjugates Prepared by Controlled Dry Heating
- Heat-induced Aggregation of Lysozyme with Ovotransferrin(Food & Nutrition)
- Heat-induced Aggregation of Lysozyme with Pepsin-treated Ovalbumin(Food & Nutrition)
- Ciliary ultrastructure in two sisters with Kartagener's syndrome
- Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation
- Properties of Heat-induced Soluble Aggregates of Ovalbumin Preheated in the Dry State
- Bactericidal Action of Lysozyme against Gram-negative Bacteria Due to Insertion of a Hydrophobic Pentapeptide into Its C-Terminus
- Secretory component (polymeric immunoglobulin receptor) expression on human keratinocytes by stimulation with interferon-γ and differences in response
- Ovomucin-Food Protein Conjugates Prepared through the Transglutaminase Reaction(Food & Nutrition)
- α_2-Macroglobulin binds to and inhibits mannose-binding protein-associated serine protease
- Deamidation of Ovalbumin during s-Ovalbumin Conversion
- Functional Properties of Deamidated Gluten Obtained by Treating with Chymotrypsin at Alkali pH(Food & Nutrition)
- Improvement of the Surface Functional Properties of β-Lactoglobulin and α-Lactalbumin by Heating in a Dry State
- Enhanced Heat-induced Gelation of β-Lactoglobulin by α-Lactalbumin
- Comparison of Conservative and Operative Treatments of Massive Rotator Cuff Tears
- Gene Expression of Procollagen α1 (I) and α1 (III) in Partial-thickness Tears of the Deep Pectoral Tendon in Chickens
- Expression of Procollagen α1 type III mRNA in Rotator Cuff Tears
- Emulsifying Properties of Protein-Polysaccharide Complexes and Hybrids(Food & Nutrition)
- Inhibition by Ovomacroglobulin of Pepsin and Rennin(Biological Chemistry)
- Effects of Phosphate Residues on the Excellent Emulsifying Properties of Phosphoglycoprotein Phosvitin(Food & Nutrition)
- Angular Momentum Transfers in Equilibrium and Pre-Equilibrium Dy(a,xn γ) Reactions
- Mediastinal Lymph Node Metastasis of Lung Cancer with an Unknown Primary Lesion Having Concurrent Endocrine Abnormality and Acanthosis Nigricans : Report of a Case
- The Role of Sialic Acid in the Functional Properties of Ovomucin(Food & Nutrition)
- Heat-induced Aggregation of Pepsin-treated Ovalbumin(Foof & Nutrition)
- Characterization of Linear Poly(N-isopropylacrylamide) and Cloud Points in its Aqueous Solutions
- Clinical significance of serum total bile acids and indocyanine green test for the estimation of plasma free etoposide ratio in anicteric hepatocellular carcinoma patients
- Photoacoustic Measurement of CdS by Transparent Transducer Method : Physical Acoustics
- Functional Protein-Polysaccharide Conjugate Prepared by Controlled Dry-heating of Ovalbumin-Dextran Mixtures(Food & Nutrition)
- 小児血液腫瘍性疾患におけるイトラコナゾール内用液による深在性真菌感染症予防の検討
- Deamidation of Lysozyme during the Storage of Egg White(Food & Nutrition)
- BINDING OF PEPSIN-TREATED HUMAN IMMUNOGLOBULIN IgG-F(ab')_2 TO THE BACTERIAL CELL SURFACE (II) : A BINDING THROUGH THE ANTIGEN-ANTIBODY REACTION
- Structural and Functional Properties of Hen Egg-white Lysozyme Deamidated by Protein Engineering
- Novel Bifunctional Lysozyme-Dextran Conjugate That Acts on Both Gram-negative and Gram-positive Bacteria(Food & Nutrition)
- WEEKLY ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG CANCER DURING CHEMOTHERAPY IN A RANDOMIZED PHASE III TRIAL
- Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy
- Hemithoracic Intensity-modulated Radiotherapy Using Helical Tomotherapy for Patients after Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
- Wiskott-Aldrich syndrome with unusual clinical features similar to juvenile myelomonocytic leukemia
- Protein Flexibility and Functional Properties of Heat-denatured Ovalbumin and lysozyme
- Functional and Structural Properties of Ovomucin
- Aggregation between Lysozyme and Heat-denatured Ovalbumin