Changes of Fibrinolytic Activity in Blood with Normal Humans in Case of the Administration of Dextran Sulphate (3g)

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We have reported that the concomitant administration of urokinase (UK) and dextran sulphate (DS) has induced higher fibrinolytic activity than that expected from the simple addition of UK alone or DS alone. For clarifying the mechanism of the accelerated (or sustained) fibrinolytic activity induced by concomitant administration of UK and DS, a large amount (3g) of DS alone was administered to the three healthy adults, and the change of the fibrinolytic activity was then estimated using fibrin plates and the content of the various factors of coagulation, fibrinolysis and kinin system in the blood were estimated by the method of single radial immunodiffusion. After DS administration, three volunteers did not have any side effects and plasmin activity in the blood increased two folds before DS administration. Furthermore, % reduction of fibrinogen content in plasma after DS administration was 19.9, that of α2-macroglobulin content was 10, that of α1-antitrypsin content was 10, that of C1'-inactivator content was 7.4, that of prothrombin content was 7.2, that of antithrombin III content was 5.6 and that of plasminogen content was 2.0. On the other hand, the fibrinolytic activity in the euglobulin fraction increased markedly after DS administration, the fibrinolytic activity curvemoved upwords and counter-clockwise. Based on the above-mentioned results, it was appeared that the acceleration of the fibrinolytic activity after the concomitant administration of UK and DS was due to decreasing the inhibitory activity of inhibitors after DS administraion alone.
一般社団法人日本臨床薬理学会の論文

Changes of Fibrinolytic Activity in Blood with Normal Humans in Case of the Administration of Dextran Sulphate (3g)

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