Time-of-day Effect of Intravenous Diazepam on Pharmacologic Actions in Man
スポンサーリンク
概要
- 論文の詳細を見る
Our group previously reported the time-of-day effect of oral administration on diazepam kinetics and its sedative action in healthy men. In these studies, it has been suggested that the absorption rate of diazempam from the gastrointestinal tract is faster in morning dosing than in evening dosing. The present study was performed to elucidate the mechanism of time-of-day effect on diazepam kinetics and dynamics, administering 5 mg diazepam (Cercine<SUP>®</SUP> injectable solution) intravenously under the same experimental conditions as the oral dose study described above. Eight healthy volunteers participated in the study. The subjects received a 5-mg dose of diazepam intravenously at 9: 30 a. m. and after a 2-wk interval, at 9: 30 p.m., in a randomly assigned cross-over study. Meals were standardized in order to fit the subjects' usual meal amount. Plasma diazempam concentrations were determined by gas chromatography (ECD). Changes in subjective feelings such as "mentally slow", "feeble", "clumsy", and "lethargic" were more marked in the morning trial at 0.5 hr after injection. More marked sedative effects were demonstrated in the morning trial by using the digit symbol substitutiontest and the continuous number addition test. Mean (±SD) total diazepam concentrations in plasma in the morning trial vs in the evening trial were: 218 (±15) vs 192 (±12) ng/ml at 0.5 hr after drug administration (0.05<P<0.1); 164 (±39) vs 132 (±16) ng/ml at 1 hr after injection (P<0.05). The results suggest that there exists time-of-day effect of intravenous injection with diazepam injectable solution onsedative actions and kinetics, which may be clinically important in some situations. Inaddition, the time-dependent kinetics of diazepam after oral dosing cannot be explainedonly by the absorption rate from the gastrointestinal tract, since intravenousadministration of diazepam did not eliminate the difference in total plasma diazepamconcentrations between morning and evening dosing at 0.5 hr and 1 hr after injection.
- 一般社団法人 日本臨床薬理学会の論文
著者
関連論文
- 単独隔離飼育と薬物効果 : Pentobarbitalによる睡眠持続時間を指標にして飼育条件とテスト時条件の観点からの検討
- II-B-62 単独隔離飼育と薬物効果 : 慢性心理的ストレス時におけるtheophyllineの急性毒性(精神薬理)(一般口演)
- I-B-7 Theophyllineの急性毒性に及ぼす心理的ストレスの影響 : 急性ストレスと慢性ストレスの比較(1.精神生理)
- 抗不安薬(diazepam)の血漿蛋白結合とその意義 : 血漿中ならびに唾液中濃度との関連性
- SI-6 生体リズムと薬物治療計画(生体リズムと心身症)
- 並木正義編集「各科領域における向精神薬の用い方 : その実際・コツ・問題点」A5,370頁, \ 5,000,1986年, カレントテラピー社刊
- 医学と薬学の接点としての臨床薬物動態学への期待(医学と薬学の接点)
- 薬効と生体リズム
- 不安の精神薬理(不安と心身症第22回日本心身医学会総会シンポジウム)
- Pharmacokineticsよりみた向精神薬物療法(心身症の薬物療法-理論と実践(基礎面))
- Experimental Studies of Anxiolytic Drug Effects on Heart Rate during Psychomotor Performance in Paired Situation
- タイトル無し
- Clinical Effect of Afloqualone (HQ-495) on Low Back Pain and Neck-Arm-Shoulder Syndrome:By a Double Blind Trial in Comparison with Tolperisone
- Pharmacokinetics of Alprazolam in Normal Subjects
- タイトル無し
- タイトル無し
- Pharmacokinetics of benzodiazepine antianxiety agent in elderly persons. Comparison between diazepan and lorazepam.
- タイトル無し
- Experimental studies on the optimal conditions of medication of oral hypogly cemic drug (gliclazide). Time relation with food intake.
- タイトル無し
- タイトル無し
- Effect on fetal toxicity of valproic acid in the dosing time.
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- Meaning of conditions of food intake in time-pharmacological study. Experimental studies.
- Effects of timing of medication and aging, on pharmacodynamics.
- Time-of-day Effect of Intravenous Diazepam on Pharmacologic Actions in Man
- :A Double-Blind Controlled Study
- タイトル無し
- Dynamic studies on the pharmacokinetics of varproic acid. Studies on the technique for prediction of blood concentration during continuous administration. 2.
- The pharmacokinetics of salicylic acid following single and repeated administration of slow-release formulations of aspirin in healthy Japanese volunteers and the effect of dosing time.
- Chronopharmacokinetic studies of valproic acid. Comparative studies between oral and intrarectal administration in mice and humans.
- Pharmacokinetics of acetylsalicylic acid and salicylic acid from slow-release formulations of aspirin in healthy Japanese volunteers.