不安の精神薬理(不安と心身症第22回日本心身医学会総会シンポジウム)

概要

論文の詳細を見る
At present, antianxiety drugs are widely prescribed for a number of different indications. They are mainly used to relieve neurotic anxiety and to induce tranquilization in patients suffering from anxiety disorders. In this paper, the following three points are discussed from our recent psychopharmacologic studies in healthy human volunteers. 1) In subjects with high trait anxiety, the antianxiety activity of benzodiazepine derivatives such as diazepam can be evaluated behaviorally in an experimentally induced stress situation. The antianxiety activity of drugs can be detected using such kind of model, differentiating from their sedative effects. 2) The relationship between plasma diazepam levels and sedative effects is demonstrated in single, but not multiple, dose studies. Both the absorption rate of drugs and the phenomenon of acute tolerance (single dose tolerance) are important to evaluate the relationship. 3) The absorption rate of diazepam from the gastrointestinal tract is influenced by personality trait such as neuroticism level of a subject. Experimentally induced stress also influences the absorption rate of diazepam in highly neurotic subjects. The gastric emptying time seems to cause these pharmacokinetic findings.
日本心身医学会の論文
1981-12-01