Pharmacokineticsよりみた向精神薬物療法(心身症の薬物療法-理論と実践(基礎面))

概要

論文の詳細を見る
Benzodiazepine derivatives and tricyclic antidepressant drugs are generally used for the treatment of psychosomatic disorders. These psychotropic drugs have several pharmacokinetic characteristics, which are as follows;(1) There is a large interindividual variation in dose/blood level ratios, especially when treatment is short term.(2) Most of them are transformed to active metabolites in the body and some of these metabolites have longer elimination half-lives than their parent componuds.(3) There is a possiblity that one drug may interact pharmacologically and pharmacokinetically with other drugs in the body.(4) Age influences the pharmacokinetics of these drugs. The elimination half-lives are prolonged in the elderly.Therefore, it would be better that dosage of these drugs be individualized according to each patient's pharmacokinetic characteristics, in the future, in order to improve the efficacy and safety of these drugs.
日本心身医学会の論文
1979-02-01