Application of Precise Accumulation Method to Analysis of Survival-time Date:Statistical Evaluation of Estrogen Therapy for Prostatic Cancer

概要

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The precise accumulation method, a new method of analysis of variance, may be more appropriate for the analysis of survival-time data than hitherto used other methods in respect of following points;<BR>1) Factors that may affect survival are compared properly over the entire period rather than at the isolated time points only. Mean lengths of survival and rates of survival at respective time points are estimated simultaneously.<BR>2) Interactions between factors and time are calculated as well as main effects of factors, hence it enables one to test the difference between patterns of survival curves.<BR>3) Uneveness of the sizes among patient groups is treated by harmonic mean method. Missing data arising from loss of follow up etc. are handled by successive approximation method.<BR>As an example of application of this method, the statistical analysis of survival-time data of prostatic cancer patients in Sapporo Medical College for evaluation of estrogen therapy was presented.
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