急性膀胱炎における抗菌剤の臨床的検討の方法 : 第1報 : 自然治癒,投与期間および投与量

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Thiamphenicol in four different daily dosages of 1500 mg, 750 mg, 375 mg, and 190 mg, and Sulfamethizolum in daily dosages of 3000 mg, 1000 mg, and 400 mg, were administered by dividing the daily dosage into three portions for two days to 65 cases of female acute cystitis caused by E. coli, and their clinical efficacy was studied. The results revealed. 1) In general the findings of patients considerably improved on the first and the second day after the administration of the drugs, in comparison with the findings at the time of first examination. 2) Among the groups to which Thiamphenicol was administered, no dose response was observed in the findings regarding the bacteria in urine and the grade of pyuria. 3) Among the groups to which Sulfamethizolum was administered, the efficacy in the dosage of 400 mg was inferior to those in the dosages of 1000 mg and 3000 mg, but no significant difference was observed between 1000 mg and 3000 mg. 4) In comparing the Thiamphenicol group with the Sulfamethizolum group, we found no significant difference between the two groups regarding the bacteriuria, while as to the grade of pyuria the Sul- famethizolum group was slightly better. From the above mentioned results, the following points were suggested. a) The clinical tests of antibacteriel drugs for acute cystitis should be performed not in comparison with the rate of natural healing, but in comparing among different type and dosage of antibacterial drugs considered to have some efficacy. b) The evaluation of efficacy may be made one day and/or two days after starting administration. Through shortening of the test period, the ethical requirements would be better satisfied and the accuracy of the test would be increased. c) It is not always impossible to seek dose response clinically in acute cystitis cases by relatively simple test, and this should be taken into consideration. The minimum dosage required for Thiamphenicol and Sulfamethizolum has been estimated to be considerably smaller than the amount conventionally regarded as an ordinary dosage.
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急性膀胱炎における抗菌剤の臨床的検討の方法 : 第1報 : 自然治癒,投与期間および投与量

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