Contribution of peripheral opioid receptors to the trimebutine-induced contractions of the proximal colon in anesthetized rats.
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agasaki, M., Yamada, K., Ikezawa, K. and Tamaki, H. <I>Contribution of peripheral opioid receptors to the trimebutine-induced contractions of the proximal colon in anesthetized rats.</I> Japanese Journal of Smooth Muscle Research, 25: 27-30, 1989<BR>In this study we investigated the involvement of opioid receptors in the contractile response to trimebutine using with the proximal colon of anesthetized rats. Trimebutine (3 mg/kg i.v.) enhanced spontaneous contractions of the proximal colon in anesthetized rats. The contractile response was partially inhibited by intravenous administration of an opioid antagonist, naloxone at 1-30μg/kg, but was hardly depressed by intracisternal administra-tion of naloxone (30μg/kg). Morphine (30μg/kg i.v.) evoked colonic contractions which were abolished by intravenous naloxone (30μg/kg). These results suggest that the colonic contractions evoked by trimebutine in anesthetized rats are, in part, mediated by peripheral opioid receptors.
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