Contractions of the stomach and duodenum induced by trimebutine in conscious fasted dogs.

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概要

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• Yamada, K. and Iizuka, M. <I>Contractions of the stomach and duodenum induced by trimebutine in conscious fasted dogs</I>. Japanese Journal of Smooth Muscle Research, 1985, 21 (1), 39-43-. Effect of trimebutine on the gastroduodenal motility was studied in conscious fasted dog with chronic implantation of electrodes and force transducers. During motor quiescence, trimebutine at 1.0-2.0 mg/kg i. v. produced action potentials and contractions similar to those developed during phase III (the period of intense action potential and contractile activity), which has been known to be physiologically important.<BR>Metoclopramide (1.0-2.0 mg/kg i. v.) induced contractile activity different from that during phase III, and hyoscine-N-butylbromide (0.1 mg/kg i. v.) produced no action potentials and contractions.

• 日本平滑筋学会の論文

著者

• 飯塚 元洋

  田辺製薬株式会社生物研究所

• 山田 健二

  田辺製薬株式会社生物研究所

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• Contractions of the stomach and duodenum induced by trimebutine in conscious fasted dogs.
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