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Effects of trimebutine maleate (TM-906) on gastrointestinal motor activity of interdigestive state were studied in seven unanaesthetized dogs by means of chroni-cally implanted force transducers.<BR>In animals which showed typical interdigestive motor pattern consisted of long lasting motor quiescence and recurring high-amplitude contractions (interdigestive contractions), intravenous infusion of TM-906 (0.6-6.0mg/kg-hr) shortened the quiescent period. During TM-906 infusion, the number and the duration of the interdigestive contractions decreased in the gastric antrum. These effects were in a dose dependent manner. Infusion of TM-906 of 6.0mg/kg-hr over 60min introduced additional responses: persistent contractions different from the usual interdigestive contractions and delayed onset of the interdigestive contractions. Metoclopramide (1.8-6.0mg/kg-hr) developed high-frequency contractions with gradually increasing amplitude and caused enhancement of the interdigestive contractions.<BR>In three animals which showed anomalous fasted motor pattern consisted of continuous low-amplitude contractions, bolus i.v. injection of TM-906 (2.0-2.5mg/kg) introduced a transient suppression of the contractions in the antrum. Metoclopramide (1.0mg/kg i.v.) potentiated and hyoscine-N-butylbromide (0.1mg/kg i.v.) inhibited the contractions in all the regions.
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