12,13-Epoxy-C-nor-D-homosteroids. VI. Reaction of 17-oxygenated 12,13-epoxyetiojervanes with boron trifluoride etherate.
スポンサーリンク
概要
- 論文の詳細を見る
17-Oxygenated 12,13-epoxyetiojerv-5-en-3-one 3,3-ethylene acetals (<B>1A</B>–<B>10A</B>) were treated with boron trifluoride etherate in benzene at room temperature. The epoxy ring cleavage reactions proceeded slowly with increase of electronegativity of the 17-substituents without and/or with deacetalization to give a variety of compounds including rearranged products (<B>23A</B> and <B>23B</B>). The results summarized in Table 1 indicated that the reactions produced compounds formed by initial cleavage at less electronegative C-12 rather than at C-13 except several compounds (<B>11A</B>, <B>20A</B>, <B>20B</B>, and <B>34A</B>). Formation of the latter compounds was attributed by hydride shift or neighboring participation of the 17-acetoxyl groups.
- 公益社団法人 日本化学会の論文
著者
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Murai Akio
Department Of Chemistry Faculty Of Science Hokkaido University
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Takeda Masami
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Masamune Tadashi
Department Of Chemistry Faculty Of Science Hokkaido University
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IWASA Noriaki
Department of Gynecologic Oncology, Saitama Medical University, International Medical Center
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